激素信号传导及信号通路串扰对子宫肌层钙动力学的调控
Hormonal signaling and signal pathway crosstalk in the control of myometrial calcium dynamics.
作者信息
Sanborn Barbara M
机构信息
Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA.
出版信息
Semin Cell Dev Biol. 2007 Jun;18(3):305-14. doi: 10.1016/j.semcdb.2007.05.007. Epub 2007 May 18.
Abstract
Understanding the basis for the control of myometrial contractant and relaxant signaling pathways is important to understanding how to manage myometrial contractions. Signaling pathways are influenced by the level of expression of the signals and signal pathway components, the location of these components in the appropriate subcellular environment, and covalent modification. Crosstalk between these pathways regulates the effectiveness of signal transduction and represents an important way by which hormones can regulate phenotype. This review deals primarily with signaling pathways that control Ca2+ entry and intracellular release, as well as the interplay between these pathways.
摘要
了解子宫肌层收缩和舒张信号通路的调控基础对于理解如何控制子宫肌层收缩至关重要。信号通路受信号及信号通路成分的表达水平、这些成分在适当亚细胞环境中的定位以及共价修饰的影响。这些通路之间的相互作用调节信号转导的有效性，是激素调节表型的重要方式。本综述主要探讨控制Ca2+内流和细胞内释放的信号通路，以及这些通路之间的相互作用。
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