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一种针对肝细胞癌自发性破裂的非常规方法。

An unusual approach to the spontaneous rupture of hepatocellular carcinoma.

作者信息

Ribeiro Marcelo Augusto Fontenelle, Fonseca Alexandre Zanchenko, Chaib Eleazar, D'Ippolito Giuseppe, Carnevale Francisco César, Rodrigues Joaquim José Gama, Saad William Abrăo

出版信息

Hepatogastroenterology. 2007 Jun;54(76):1235-8.

Abstract

Our aim is to describe an unusual approach to the spontaneous rupture of a large hepatocellular carcinoma (HCC). A 45-year-old man, Hepatitis C virus (+) (HCV+), complaining of abdominal pain. During the investigation, a tumor affecting liver segments V, VI, VII and VIII, with the presence of fluid within the peritoneal cavity, suggesting hemoperitoneum, was found. The patient was submitted to an exploratory laparotomy, revealing a large hepatic tumor mass with capsule rupture in segment V, biopsy verified the diagnosis of HCC. After one week, a superselective chemoembolization of the nutrient artery of the tumor was performed; one month later, the patient was submitted to an embolization of the right portal branch, aimed at causing hypertrophy of the left lateral portion of the liver. A right hepatectomy was performed, as well as a nodulectomy in segment II, without complications along the 40 days subsequent to the portal embolization. The patient is currently on his 53rd postoperative month and evidences no tumor recurrence to the moment. Although the spontaneous rupture of HCC is uncommon, it can be today treated by combining interventionist radiology procedures and conventional liver resections, offering the patient a better chance of survival.

摘要

我们的目的是描述一种针对大肝细胞癌(HCC)自发性破裂的非常规治疗方法。一名45岁男性,丙型肝炎病毒阳性(HCV+),主诉腹痛。在检查过程中,发现一个累及肝段V、VI、VII和VIII的肿瘤,腹腔内有液体,提示腹腔积血。患者接受了剖腹探查术,发现肝内有一个巨大肿瘤肿块,V段有包膜破裂,活检证实为HCC。一周后,对肿瘤的滋养动脉进行了超选择性化疗栓塞;一个月后,对患者进行了右门静脉分支栓塞,目的是使肝左外侧部分肥大。进行了右肝切除术以及II段结节切除术,在门静脉栓塞后的40天内无并发症。患者目前处于术后第53个月,目前未发现肿瘤复发。尽管HCC的自发性破裂并不常见,但如今通过结合介入放射学程序和传统肝脏切除术可以进行治疗,为患者提供更好的生存机会。

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