Filiz Gulaydan, Yerci Omer, Adim Saduman Balaban, Gurel Selim, Dolar Enver, Memik Faruk
Department of Surgical Pathology, Uludag University Faculty of Medicine, Bursa, Turkey.
Hepatogastroenterology. 2007 Jun;54(76):1247-9.
BACKGROUND/AIMS: The purpose of this study was to determine predictors of survival after resection for periampullary neoplasms.
In this study, we reevaluated our 17 cases of this type tumor which we had reported as periampullar site tumors, in advanced stages with undetermined localization, in our pathology department of the Uludag University faculty of medicine.
Six of our cases were female, and 11 were male with a mean age of 60.6 years (range 31-77). Their main complaints were loss of weight, anorexia, jaundice and fatigue. Physical and endoscopic examination of these patients revealed periampullary mass and Whipple operations were performed on all of them. Histopathologic examinations of these tumors revealed adenocarcinoma in 15, small cell (neuroendocrin) carcinoma in two. All were in the advanced stages. Eight of them were alive and free of disease after 1.5- to 20-month follow-ups, while ten died because of disease.
Periampullary carcinoma is a problem with increasing clinical significance. Tumor size, tumor type and differentiation, lymph node status appears to be prognostic markers.
背景/目的：本研究旨在确定壶腹周围肿瘤切除术后的生存预测因素。
在本研究中，我们重新评估了在乌鲁达大学医学院病理科报告的17例此类肿瘤病例，这些病例最初被报告为壶腹周围部位肿瘤，处于晚期且定位不明。
我们的病例中有6例为女性，11例为男性，平均年龄为60.6岁（范围31 - 77岁）。他们的主要症状是体重减轻、厌食、黄疸和疲劳。对这些患者进行体格检查和内镜检查发现壶腹周围肿块，并对所有患者进行了惠普尔手术。这些肿瘤的组织病理学检查显示15例为腺癌，2例为小细胞（神经内分泌）癌。所有病例均处于晚期。其中8例在1.5至20个月的随访后存活且无疾病，而10例因疾病死亡。
壶腹周围癌是一个临床意义日益增加的问题。肿瘤大小、肿瘤类型和分化程度、淋巴结状态似乎是预后标志物。
