Oliviero A, Rubio-Esteban M, Foffani G, Aguilar J, Lopez-Dolado E, Arzoz-Lezaun T, Godino-Duran J A, Gómez-Argüelles J M, Pérez-Borrego Y, de la Cruz F Sebastián, Di Lazzaro V
FENNSI Group, Hospital Nacional de Parapléjicos, SESCAM, Finca La Peraleda s/n, 45071 Toledo, Spain.
Neurosci Res. 2007 Sep;59(1):89-92. doi: 10.1016/j.neures.2007.06.1463. Epub 2007 Jun 13.
The aim of this study was to evaluate the effect of chronic consumption of the GABAB agonist baclofen on temperature perception in humans. We investigated temperature perception thresholds to detect warm and cold stimuli in a group of 21 patients with spinal cord injury, who were chronically consuming oral baclofen at different daily doses to treat spasticity. Temperature perception thresholds were assessed above the level of the lesion, using a psychophysical approach based on the ability of the subjects to perceive precisely quantified sensory stimuli (quantitative sensory testing, QST). The data were compared with a control group of healthy subjects, not receiving baclofen. We found that chronic baclofen consumption increased temperature perception thresholds for both cold and warm stimuli in a dose-dependent manner. Temperature perception thresholds did not depend on the level of the lesion nor on the duration of baclofen treatment, suggesting that our finding represent normal GABAB-mediated modulation in spared nervous structures. We conclude that GABAB therefore plays a role in temperature perception in humans.
本研究的目的是评估长期服用GABAB激动剂巴氯芬对人体温度感知的影响。我们调查了一组21名脊髓损伤患者的温度感知阈值，这些患者长期服用不同日剂量的口服巴氯芬来治疗痉挛。使用基于受试者精确感知定量感觉刺激能力的心理物理学方法（定量感觉测试，QST），在损伤水平以上评估温度感知阈值。将数据与未服用巴氯芬的健康受试者对照组进行比较。我们发现，长期服用巴氯芬会以剂量依赖的方式提高冷刺激和热刺激的温度感知阈值。温度感知阈值不取决于损伤水平，也不取决于巴氯芬治疗的持续时间，这表明我们的发现代表了在保留的神经结构中正常的GABAB介导的调节。我们得出结论，因此GABAB在人类温度感知中发挥作用。
