Hammer J, Grädel E, Signer E, Ohnacker H, Rinderknecht B P, Rutishauser M
Universitätskinderklinik Basel.
Pneumologie. 1991 Nov;45(11):932-5.
Isolated primary tumors of the lung are rarely seen in childhood and are benign in one third of the patients. Plasma cell granulomas represent the most common benign tumor of the lung in this age group. Histologically, the tumor is characterized by the various components of a chronic inflammation or granulation tissue. Frozen sections can pose difficulties in the differentiation between a malignant and benign process. In view of the case history of our patient we set out to demonstrate that a knowledge of the clinical picture and a correct interpretation of associated laboratory findings facilitate diagnosis. To our knowledge we describe for the first time the ultrastructural findings of so-called "microtubule-reticular structures" giving further evidence of the inflammatory origin of this lesion.
孤立性原发性肺肿瘤在儿童时期很少见，三分之一的患者为良性。浆细胞肉芽肿是该年龄组最常见的肺部良性肿瘤。在组织学上，该肿瘤的特征是具有慢性炎症或肉芽组织的各种成分。冰冻切片在鉴别恶性和良性过程中可能存在困难。鉴于我们患者的病史，我们着手证明了解临床情况和正确解释相关实验室检查结果有助于诊断。据我们所知，我们首次描述了所谓“微管网状结构”的超微结构发现，进一步证明了该病变的炎症起源。
