Björkman Per, Flamholc Leo, Molnegren Vilma, Marshall Aline, Güner Nuray, Widell Anders
Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden.
AIDS. 2007 Jul 31;21(12):1641-3. doi: 10.1097/QAD.0b013e32823bc9b7.
In patients co-infected with HIV-1 and GB virus C (GBV-C), the disappearance of GBV-C RNA has been associated with accelerated disease progression. We studied longitudinal GBV-C viral titres in 28 HIV-1/GVB-C co-infected individuals receiving HAART. During HAART, median GBV-C RNA titres increased from 95 to 6000 copies/ml (P < 0.001). In patients interrupting HAART, GBV-C-RNA titres decreased as HIV replication resumed. These findings further support the theory that GBV-C replication could depend on the dynamics of HIV progression.
在同时感染人类免疫缺陷病毒-1（HIV-1）和GB病毒C（GBV-C）的患者中，GBV-C RNA的消失与疾病进展加速有关。我们研究了28名接受高效抗逆转录病毒治疗（HAART）的HIV-1/GBV-C合并感染个体的GBV-C病毒载量变化情况。在HAART期间，GBV-C RNA载量中位数从95拷贝/毫升增加到6000拷贝/毫升（P<0.001）。在中断HAART的患者中，随着HIV复制的恢复，GBV-C RNA载量下降。这些发现进一步支持了GBV-C复制可能取决于HIV进展动态的理论。
