de Witte P, Dreessen M, Lemli J
Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Instituut voor Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Belgium.
Pharm Acta Helv. 1991;66(3):70-3.
The secretagogue activity of 30 different anthracene and diphenylmethane derivatives was investigated by determining their influence on water, sodium and potassium absorption in the gastrointestinal tract of the rat by direct administration into the rat colon. To obtain an effect two phenolic groups are necessary. However the distance between these groups seems to be a major factor for secretagogue activity. In the case of the anthranoids an intact anthraquinone or anthrone structure is a prerequisite.
通过将30种不同的蒽和二苯甲烷衍生物直接注入大鼠结肠，测定它们对大鼠胃肠道水、钠和钾吸收的影响，研究了这些衍生物的促分泌活性。要产生作用，两个酚羟基是必需的。然而，这些基团之间的距离似乎是促分泌活性的主要因素。对于蒽类化合物而言，完整的蒽醌或蒽酮结构是前提条件。
