Cervera A, Amaro S, Obach V, Chamorro A
Stroke Unit, Institut of Clinical Neurosciences, Hospital Clinic, University of Barcelona and Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Curr Drug Targets. 2007 Jul;8(7):824-31. doi: 10.2174/138945007781077427.
Ischemic stroke secondary to cardiac disease accounts for approximately 30% of all stroke subtypes and it may be due to a large list of conditions. Stroke secondary to heart disease causes more severe deficits, higher mortality, and increased costs that other stroke subtypes. Therefore, proper identification of cardioembolic stroke is crucial for adequate selection of optimal preventive strategies. Identification of stroke prone individuals with heart disease could also have an important therapeutic impact. This manuscript reviews the interaction between the heart and brain with a particularly emphasis in the current state of older and newer antithrombotic drugs for stroke prevention in patients with atrial fibrillation. Other neuro-cardiological issues reviewed include current antithrombotic strategies in patients with a host of heart conditions which include pacemakers, acute myocardial infarction, congestive heart failure, cardiac procedures, patent foramen ovale, valve disease, endocarditis, or cardiac tumours.
继发于心脏病的缺血性中风约占所有中风亚型的30%，其病因可能多种多样。继发于心脏病的中风会导致比其他中风亚型更严重的功能缺损、更高的死亡率以及更高的成本。因此，正确识别心源性栓塞性中风对于适当选择最佳预防策略至关重要。识别易患中风的心脏病患者也可能具有重要的治疗意义。本手稿回顾了心脏与大脑之间的相互作用，特别强调了用于预防房颤患者中风的新旧抗血栓药物的现状。所回顾的其他神经心脏病学问题包括患有多种心脏疾病（包括起搏器、急性心肌梗死、充血性心力衰竭、心脏手术、卵圆孔未闭、瓣膜病、心内膜炎或心脏肿瘤）患者的当前抗血栓策略。
