Diffusion of naproxen in presence of beta-cyclodextrin across a silicone rubber membrane.

The diffusion of Naproxen through a silicone rubber membrane has been studied for four different release systems: solution and suspension both of Naproxen and Naproxen beta-cyclodextrin coprecipitates. Differences in transport between the two forms indicate the existence of an interaction between the acid and beta-cyclodextrin in solution. Independence of the transport on pH in the case of the coprecipitate indicates rapid liberation of Naproxen from the complex prior to entering the membrane. Increase in the cumulative amount diffused for the suspension of Naproxen with increasing pH was interpreted as due to an increase in its solubility with increasing pH.