生殖细胞：世代之间的永恒纽带。

Germ cells: the eternal link between generations.

作者信息

Surani M Azim

机构信息

Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

出版信息

C R Biol. 2007 Jun-Jul;330(6-7):474-8. doi: 10.1016/j.crvi.2007.03.009. Epub 2007 May 9.

DOI:10.1016/j.crvi.2007.03.009

PMID:17631440

Abstract

The pluripotent epiblast cells in the early embryo are destined to form both the somatic cells and primordial germ cells. In the few cells that undergo specification to establish the germ cell lineage, there is repression of the somatic programme. Recent evidence shows that, Blimp1, a known transcriptional repressor with a SET/PR domain, is crucial for the specification of primordial germ cells (PGC). Blimp1 has the role, at least in part, of suppressing the somatic programme.

摘要

早期胚胎中的多能上胚层细胞注定会形成体细胞和原始生殖细胞。在少数经历特化以建立生殖细胞谱系的细胞中，体细胞程序受到抑制。最近的证据表明，Blimp1是一种已知的具有SET/PR结构域的转录抑制因子，对原始生殖细胞（PGC）的特化至关重要。Blimp1至少部分地起到抑制体细胞程序的作用。