Ewald Andreas H, Fritschi Giselher, Maurer Hans H
Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D-66421, Homburg (Saar), Germany.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 15;857(1):170-4. doi: 10.1016/j.jchromb.2007.06.027. Epub 2007 Jul 1.
The amphetamine-derived designer drug 4-iodo-2,5-dimethoxy-amphetamine (DOI) is an upcoming substance on the illicit drug market. In the current study, the identification of its metabolites in rat urine and their toxicological detection in the authors' systematic toxicological analysis (STA) procedure were examined. DOI is extensively metabolized by O-demethylation and beside small amounts of parent compound it was found to be excreted mainly in form of metabolites. The STA procedure using full-scan GC-MS allowed proving an intake of a common drug users' dose of DOI by detection of the two O-demethyl metabolite isomers in rat urine. Assuming similar metabolism, the described STA procedure should be suitable for proof of an intake of DOI in human urine.
苯丙胺类合成毒品4-碘-2,5-二甲氧基苯丙胺（DOI）是非法毒品市场上一种新兴物质。在本研究中，对其在大鼠尿液中的代谢产物进行了鉴定，并在作者的系统毒理学分析（STA）程序中对其进行了毒理学检测。DOI通过O-去甲基化广泛代谢，除少量母体化合物外，主要以代谢产物的形式排泄。使用全扫描气相色谱-质谱联用的STA程序能够通过检测大鼠尿液中的两种O-去甲基代谢物异构体来证明普通吸毒者剂量的DOI摄入情况。假设代谢情况相似，所描述的STA程序应适用于证明人尿液中DOI的摄入情况。
