De Smet Y, Jaminet M, Jaeger U, Jacob J, Neuray H, Haus G, Ledesch-Camus D, Meyers R
Neurologie, Clinique Saint-Louis, Hôpital Régional du Nord, Ettelbruck, Grand-Duché de Luxembourg.
Rev Neurol (Paris). 1991;147(10):682-5.
A patient, treated by mechanical ventilation with pancuronium or atracurium and with intravenously administered corticosteroid for status asthmaticus, presented with rhabdomyolysis (severe amyotrophy and marked of creatine kinase activity) and acute flacid and areflexic quadriplegia, involving the proximal and distal muscles but sparing the cephalic musculature. After review of the investigations (biochemistry, electromyogram, muscle biopsy), the diagnostic of acute corticosteroid myopathy following status asthmaticus was suggested, and a pancuronium neuromuscular complication or a critically ill polyneuropathy excluded. The non-inflammatory rhabdomyolysis concerned all the fiber types. Predominantly distal weakness resolved six months after the insult, in spite of the laboratory recurrence of the rhabdomyolysis at the time of a new status asthmaticus briefly treated with corticosteroid.
一名因哮喘持续状态接受泮库溴铵或阿曲库铵机械通气及静脉注射皮质类固醇治疗的患者，出现横纹肌溶解（严重肌萎缩和肌酸激酶活性显著升高）以及急性弛缓性和无反射性四肢瘫，累及近端和远端肌肉，但头面部肌肉未受累。在对各项检查（生化、肌电图、肌肉活检）进行评估后，提示诊断为哮喘持续状态后急性皮质类固醇肌病，排除了泮库溴铵神经肌肉并发症或危重病性多发性神经病。非炎性横纹肌溶解累及所有纤维类型。尽管在再次出现哮喘持续状态并短期接受皮质类固醇治疗时实验室检查显示横纹肌溶解复发，但主要的远端肌无力在损伤后6个月得到缓解。
