Lu Ya-xin, He Hai-bing, Cui Yue, Tang Xing
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yao Xue Xue Bao. 2007 Apr;42(4):445-9.
To study the rheological properties of sucrose acetate isobutyrate (SAIB) in situ gel and the influencing factors. Measurements of shear stress and viscosity were carried out at different shear rate. The rheological properties of SAIB solution were similar to those of Newtonian fluid. The factors such as the type of solvent, concentration, additive, drug and temperature had effect on the rheological properties. Ethanol was a suitable solvent compared with ethyl lactate and N-methylpyrrolidone (NMP). The solution viscosity of SAIB was reduced from 1.29 to 0.11 Pa x s with only increasing the content of ethanol from 10% to 20%. Polylactic acid (PLA) and risperidone could increase the intermolecular force and viscosity. However, adding 10% (w/w) PLA, the initial release of risperidone was reduced from 20.2% to 3.5%. The solution viscosity reduced significantly by stepping up the temperature. The results obtained support the using of SAIB is satisfactorily injectable in situ gel formulation.
研究醋酸异丁酸蔗糖酯（SAIB）原位凝胶的流变学性质及其影响因素。在不同剪切速率下进行剪切应力和粘度的测量。SAIB溶液的流变学性质与牛顿流体相似。溶剂类型、浓度、添加剂、药物和温度等因素对流变学性质有影响。与乳酸乙酯和N-甲基吡咯烷酮（NMP）相比，乙醇是一种合适的溶剂。仅将乙醇含量从10%增加到20%，SAIB的溶液粘度就从1.29降低到0.11 Pa·s。聚乳酸（PLA）和利培酮可增加分子间作用力和粘度。然而，添加10%（w/w）的PLA，利培酮的初始释放率从20.2%降至3.5%。升高温度会使溶液粘度显著降低。所得结果支持SAIB可令人满意地用于注射用原位凝胶制剂。
