[年龄及绝经起始时间对健康女性血脂状况、低密度脂蛋白氧化及C反应蛋白的影响]

Caparević Zorica, Kostić Nada

Srp Arh Celok Lek. 2007 May-Jun;135(5-6):280-5. doi: 10.2298/sarh0706280c.

INTRODUCTION

Atherogenic lipid profile is an important risk factor in development of atherosclerosis in menopausal women. High level of small dense LDL, that is more susceptible to oxidation, and high levels of inflammatory markers are also associated with an increased risk for development of atherosclerosis.

OBJECTIVE

The aim of this study was to investigate the relationship between lipid profile, oxidized LDL (Ox-LDL) and C-reactive protein (CRP) as inflammatory reaction in healthy women dependent on age and menopause.

METHOD

The study included a group of clinically healthy women (total of 97 women). Group 1: 15 women younger than 45 years; group 2:62 women between 46 and 55 years, group 3: 20 women between 56 and 65 years, group of menopausal women (73) and group of premenopausal women (24). None of the women had history of obesity, diabetes mellitus, cerebrovascular, ischaemic heart disease, and hypertension. Lipid profiles were measured by enzymatic methods. Ox-LDL was measured by using a specific monoclonal antibody, mAb4E6. CRP was measured using hemiluminiscent methods (Immulite-DPC).

RESULTS

Results showed significantly higher levels of total cholesterol (p < 0.01) and LDL cholesterol (p < 0.01) in women over 56 years compared with women younger than 45 years. We also found similar results in menopausal women. Levels of Ox-LDL (p < 0.05) and CRP (p < 0.01) showed significantly higher levels in women over 56 years. In menopausal women, we found significantly higher levels of CRP (p < 0.05). There was no significant difference in the levels of oxLDL between the menopausal and premenopausal women. Levels of triglycerides and HDL cholesterol were not different among groups. We found that 51% women had levels of HDL cholesterol lower than 1.3 mmol/L. In all groups of women, we found positive correlation among age, Ox-LDL (p < 0.01) and CRP (p < 0.01). Ox-LDL also positively correlated with CRP (p < 0.01).

CONCLUSION

In healthy women older than 56 as in menopausal women, we found significantly higher levels of LDL cholesterol and inflammatory markers. These results suggest that strategies of primary prevention in women are needed to reduce the risk of developing cardiovascular disease.

引言

致动脉粥样硬化性脂质谱是绝经后女性动脉粥样硬化发生发展的重要危险因素。高水平的小而密低密度脂蛋白（更易氧化）以及高水平的炎症标志物也与动脉粥样硬化发生风险增加相关。

目的

本研究旨在探讨健康女性中脂质谱、氧化型低密度脂蛋白（Ox-LDL）和作为炎症反应指标的C反应蛋白（CRP）与年龄及绝经状态之间的关系。

方法

该研究纳入一组临床健康女性（共97名）。第1组：15名年龄小于45岁的女性；第2组：62名年龄在46至55岁之间的女性；第3组：20名年龄在56至65岁之间的女性，绝经后女性组（73名）和绝经前女性组（24名）。这些女性均无肥胖、糖尿病、脑血管疾病、缺血性心脏病及高血压病史。采用酶法测量脂质谱。使用特异性单克隆抗体mAb4E6测量Ox-LDL。采用半发光法（免疫发光分析仪-DPC）测量CRP。

结果

结果显示，56岁以上女性的总胆固醇（p < 0.01）和低密度脂蛋白胆固醇（p < 0.01）水平显著高于45岁以下女性。在绝经后女性中我们也发现了类似结果。56岁以上女性的Ox-LDL水平（p < 0.05）和CRP水平（p < 0.01）显著更高。在绝经后女性中，我们发现CRP水平显著更高（p < 0.05）。绝经后女性和绝经前女性的Ox-LDL水平无显著差异。各组间甘油三酯和高密度脂蛋白胆固醇水平无差异。我们发现51%的女性高密度脂蛋白胆固醇水平低于1.3 mmol/L。在所有女性组中，我们发现年龄、Ox-LDL（p < 0.01）和CRP（p < 0.01）之间呈正相关。Ox-LDL与CRP也呈正相关（p < 0.01）。