Caparević Zorica, Kostić Nada, Ilić Sanja, Radojković Jana, Marina Djordje, Pencić Biljana, Radojković Ivan
Srp Arh Celok Lek. 2009 Mar-Apr;137(3-4):140-5. doi: 10.2298/sarh0904140c.
Elevated levels of oxidized LDL cholesterol (OxLDL) are considered to be a key factor of initiating and accelerating atherosclerosis. It promotes atherosclerosis through inflammatory and immunologic mechanisms that lead to the formation of macrophage foam cells.
To determine the relationship among OxLDL, C-reactive protein (CRP) level and carotid intima-media thickness (IMT) in population with risk factors for atherosclerosis.
The study group consisted of 125 clinically healthy, hypercholesterolaemic subjects (49.3 +/- 5.7 years; 75 females and 50 males) compared with 100 age-matched population-based control subjects. The study group was divided into two subgroups: subgroup A (the levels of LDL cholesterol > 5 mmol/L) and subgroup B (the levels of LDL cholesterol < 5 mmol/L). None of the subjects had history of cerebrovascular, ischaemic heart disease, hypertension or diabetes mellitus. Lipid profiles were measured by enzymatic methods. OxLDL was measured by using a specific monoclonal antibody, mAb4E6. CRP was measured using hemiluminescent methods (Immulite-DPC). The common carotid IMT was measured by the B-mode ultrasound.
Compared to controls, the study group had higher levels of OxLDL (119.97 +/- 43.15 vs. 82.03 +/- 25.99 IU/L; p < 0.01) and CRP (6.20 +/- 3.55 vs. 2.68 +/- 3.04 mg/ml; p < 0.05). IMT was significantly higher in study subjects (1.14 +/- 0.38 vs. 0.72 +/- 0.24 mm; p < 0.05). We also found that, in the whole study group, IMT significantly positively correlated with OxLDL (r = 0.442; p < 0.05). We found that in the study subgroup A, IMT positively correlated with CRP (r = 0.792; p < 0.01). In controls, we found a significantly positive association between IMT and OxLDL (r = 0.781; p < 0.01) and CRP (r = 0.748; p < 0.01).
The elevated levels of OxLDL and CRP are associated with higher common carotid intima-media thickness in population with risk factors for atherosclerosis.
氧化型低密度脂蛋白胆固醇（OxLDL）水平升高被认为是引发和加速动脉粥样硬化的关键因素。它通过导致巨噬细胞泡沫细胞形成的炎症和免疫机制促进动脉粥样硬化。
确定动脉粥样硬化危险因素人群中OxLDL、C反应蛋白（CRP）水平与颈动脉内膜中层厚度（IMT）之间的关系。
研究组由125名临床健康的高胆固醇血症受试者（49.3±5.7岁；75名女性和50名男性）组成，与100名年龄匹配的基于人群的对照受试者进行比较。研究组分为两个亚组：A亚组（低密度脂蛋白胆固醇水平>5 mmol/L）和B亚组（低密度脂蛋白胆固醇水平<5 mmol/L）。所有受试者均无脑血管疾病、缺血性心脏病、高血压或糖尿病病史。采用酶法测量血脂谱。使用特异性单克隆抗体mAb4E6测量OxLDL。采用半发光法（Immulite-DPC）测量CRP。采用B型超声测量颈总动脉IMT。
与对照组相比，研究组的OxLDL水平更高（119.97±43.15 vs. 82.03±25.99 IU/L；p<0.01），CRP水平更高（6.20±3.55 vs. 2.68±3.04 mg/ml；p<0.05）。研究对象的IMT显著更高（1.14±0.38 vs. 0.72±0.24 mm；p<0.05）。我们还发现，在整个研究组中，IMT与OxLDL显著正相关（r = 0.442；p<0.05）。我们发现，在研究亚组A中，IMT与CRP正相关（r = 0.792；p<0.01）。在对照组中，我们发现IMT与OxLDL（r = 0.781；p<0.01）和CRP（r = 0.748；p<0.01）之间存在显著正相关。
在有动脉粥样硬化危险因素的人群中，OxLDL和CRP水平升高与颈总动脉内膜中层厚度增加有关。
