Rusakov A V, Medvinskiĭ A B, Pogorelov A G
Biofizika. 2007 May-Jun;52(3):555-9.
The 3D structure of the heart tissue of Wistar rats from different age groups has been reconstructed by light microscopy of consecutive series of semithin sections. At the histological resolution level, connective tissue segments in the myocardium of aged (18 months) animals were found, while in the myocardium of young (2 months) animals no connective tissue segments were observed. A mathematical model and the results of the 3D reconstruction were used to simulate the formation of excitation wave circulation in the myocardium. The values of conductivity and the excitability threshold, and the pulse frequency rates were found at which the disturbances of the heart rhythm resulting from the excitation wave circulation are predicted by the mathematical modeling.
