Russo S, Botti G, Vinaccia P, Iaccarino C, Maioli S, Del Prete D, Maiello F M
U.O.C. di Anatomia Patologica, Ospedale dei Pellegrini, Napoli. Italy.
Pathologica. 2007 Apr;99(2):46-9.
Urothelium can show several pseudoneoplastic lesions. Mimic lesions diagnosis is therapeutically and prognostically critical but it is often difficult on the basis of morphology alone in bladder biopsy specimen. We studied in a retrospective way an immunohistochemical panel that helps in this differential diagnosis. The panel includes antibodies against cytokeratin 20 (CK20), CD44, Ki67 (MIB-1) e p53 and we applied it to 31 cases of non-neoplastic urothelium (26 urothelial biopsies with reactive atypia and 5 normal urothelium) and 50 cases of urothelial neoplasia where we analized the distribution of the markers over the urothelium. We obtained two different "standard" results, for neoplastic and non-neoplastic urothelium. We were able to prove that this panel is useful, non expensive tool in the differential diagnosis of urothelial proliferative lesions.
尿路上皮可表现出几种假性肿瘤性病变。模仿性病变的诊断在治疗和预后方面至关重要，但仅根据膀胱活检标本的形态学往往很难诊断。我们回顾性研究了一组有助于这种鉴别诊断的免疫组织化学指标。该指标包括抗细胞角蛋白20（CK20）、CD44、Ki67（MIB-1）和p53的抗体，我们将其应用于31例非肿瘤性尿路上皮病例（26例有反应性异型性的尿路上皮活检和5例正常尿路上皮）以及50例尿路上皮肿瘤病例，分析了这些标志物在尿路上皮中的分布情况。我们获得了肿瘤性和非肿瘤性尿路上皮两种不同的“标准”结果。我们能够证明该指标是鉴别尿路上皮增生性病变的有用且廉价的工具。
