[结核分枝杆菌耐药菌株对结核病复发的影响]

[The impact of resistant strains of Mycobacterium tuberculosis on relapse of tuberculosis].

作者信息

Videnović-Ivanov Jelica, Vucinić-Mihailović Violeta, Mandarić Dragan

机构信息

Institut za plućne bolesti i tuberkulozu, Klinicki centar Srbije, Beograd.

出版信息

Med Pregl. 2006 Nov-Dec;59(11-12):522-5. doi: 10.2298/mpns0612522v.

Abstract

INTRODUCTION

Relapses of tuberculosis are fairly rare nowdays and they represent the onset of tuberculosis two, or more than two years after completion of previous treatment.

MATERIAL AND METHODS

In the previous period, relapses of tuberculosis occurred in 141 patients (87 male and 54 female). Their mean age was 46.2 years.

RESULTS

Relapses of tuberculosis occurred after 11.3 years, on average. All patients presented with pulmonary tuberculosis, and two patients also had pulmonary and extrapulmonary tuberculosis (bones). Resistance was one of the statistically significant factors for relapse of tuberculosis. Resistance to one antituberculotic agent was most common--8 patients, resistance to two drugs--4 patients, resistance to three drugs--4 patients, resistance to four drugs in 5 patients. Due to these findings on resistant strains of mycobacterium tuberculosis, a huge number of patients with relapses of tuberculosis had full recovery and completed the treatment.

CONCLUSION

The importance of resistant strains of mycobacterium tuberculosis is really huge in our conditions. The findings of these resistant strains of mycobacterium tuberculosis and adequate medical treatment are obligatory nowadays.

摘要

引言

如今,结核病复发相当罕见,它指的是在上一疗程治疗结束两年或两年以上后结核病的再次发作。

材料与方法

在此前阶段,141例患者(87例男性和54例女性)出现了结核病复发。他们的平均年龄为46.2岁。

结果

结核病复发平均发生在11.3年后。所有患者均表现为肺结核,2例患者还患有肺外结核(骨骼)。耐药性是结核病复发的统计学显著因素之一。对一种抗结核药物耐药最为常见——8例患者,对两种药物耐药——4例患者,对三种药物耐药——4例患者,对四种药物耐药5例患者。基于对结核分枝杆菌耐药菌株的这些发现,大量结核病复发患者实现了完全康复并完成了治疗。

结论

在我们的情况下,结核分枝杆菌耐药菌株的重要性确实巨大。如今,发现这些结核分枝杆菌耐药菌株并进行适当的医学治疗是必不可少的。

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