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[高血压、先兆子痫和子痫——妊娠监测与结局]

[Hypertension, pre-eclampsia and eclampsia--monitoring and outcome of pregnancy].

作者信息

Grujić Ilija, Milasinović Ljubomir

机构信息

Zdravstveni centar "Veljko Vlahović", Vrbas.

出版信息

Med Pregl. 2006 Nov-Dec;59(11-12):556-9. doi: 10.2298/mpns0612556g.

Abstract

Pregnancy-induced hypertension, pre-eclampsia and eclampsia are parts of the hypertensive syndrome which is a life-threatening condition both for mother and fetus. Apart from being associated with unpredictable onset, it is incurable, except by ending the pregnancy. Its incidence is approximately between 6 - 10% of pregnant women. There is no unique definition and classification of the hypertensive syndrome in pregnancy, i.e. they differ from one expert group to another. RISKS OF PREGNANCY-INDUCED HYPERTENSION: Pregnancy-induced hypertension syndrome can cause placental abruption, intracranial hemorrhage, liver lesions, acute renal disorders and disseminated intravascular coagulation (DIC), adult respiratory distress syndrome (ARDS), hypervolemia and inhalation of gastric content, due to deep sedation. TREATMENT OF PREGNANCY-INDUCED HYPERTENSION: Delivery is always appropriate therapy for the mother, but may not be a good solution for the fetus. Standard treatment of preeclampsia includes: anticonvulsive therapy, antihypertensive therapy, excessive fluid administration, and if necessary, management of oliguria, DIC, pulmonary edema and recovery of liver function. THE OUTCOME OF PREGNANCY-INDUCED HYPERTENSION (PERINATAL AND MATERNAL MORTALITY): Maternal mortality due to pregnancy-induced hypertension is 15 - 33% out of the total number of maternal deaths. Newborn infants of mothers with pregnancy-induced hypertension present with intrauterine growth retardation, prematurity, dysmaturity and necrotizing enterocolitis. Pregnancy-induced hypertension is one of the major causes of maternal and fetal/neonatal morbidity and mortality.

摘要

妊娠高血压、子痫前期和子痫是高血压综合征的一部分,这是一种对母亲和胎儿都有生命威胁的疾病。除了发病不可预测外,这种疾病无法治愈,除非终止妊娠。其发病率约占孕妇的6%-10%。妊娠高血压综合征没有统一的定义和分类,即不同专家小组的定义和分类有所不同。妊娠高血压的风险:妊娠高血压综合征可导致胎盘早剥、颅内出血、肝脏病变、急性肾脏疾病和弥散性血管内凝血(DIC)、成人呼吸窘迫综合征(ARDS)、血容量过多以及因深度镇静导致的胃内容物吸入。妊娠高血压的治疗:分娩对母亲来说始终是合适的治疗方法,但对胎儿可能并非最佳解决方案。子痫前期的标准治疗包括:抗惊厥治疗、降压治疗、过度补液,必要时处理少尿、DIC、肺水肿和肝功能恢复。妊娠高血压的结局(围产期和孕产妇死亡率):妊娠高血压导致的孕产妇死亡占孕产妇死亡总数的15%-33%。患有妊娠高血压的母亲所生的新生儿会出现宫内生长受限、早产、发育不良和坏死性小肠结肠炎。妊娠高血压是孕产妇和胎儿/新生儿发病和死亡的主要原因之一。

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