β-环糊精聚合物微球的合成及其药物释放行为
[Synthesis of beta-cyclodextrin polymer beads and its behavior of drug release].
作者信息
Wu Wen-juan, Zheng Dun-sheng, Cai Shi-tian, Huang Yuan-keng
机构信息
Department of Physical Chemistry, Guangdong Pharmaceutical University, Guangzhou 510006, China.
出版信息
Zhong Yao Cai. 2007 Mar;30(3):329-32.
OBJECTIVE
To prepare beta-cyclodextrin polymer (beta-CDP) beads using as a drug carrier and study the release behaviors of Berberine Hydrochlorrde (BH) in beta-CDP beads.
METHODS
beta-CDP beads were synthesized by inverse emulsion polymerization. The inclusion complex between beta-CD and BH were investigated by phase solubility method. And the release of BH in vitro was studied by UV spectra.
RESULTS
Inclusion compounds of beta-CD and BH with 1: 1 molar ratio were found under the condition of pH 1.4 and pH 7.4, with corresponding stability constants of 48.85 L/mol and 122.11 L/mol, respectively. Finally, the controlled release behavior of BH in polymer beads were studied and the release rate of BH kept almost constant after 24 h. Release rate of BH was higher at pH 1.4 than that at pH 7.4.
CONCLUSION
beta-CDP beads may be an ideal controlled drug release carrier.
目的
制备β-环糊精聚合物（β-CDP）微球作为药物载体，并研究盐酸小檗碱（BH）在β-CDP微球中的释放行为。
方法
采用反相乳液聚合法合成β-CDP微球。用相溶解度法研究β-环糊精（β-CD）与BH的包合物。通过紫外光谱研究BH的体外释放。
结果
在pH 1.4和pH 7.4条件下，发现β-CD与BH形成摩尔比为1:1的包合物，相应的稳定常数分别为48.85 L/mol和122.11 L/mol。最后，研究了BH在聚合物微球中的控释行为，24 h后BH的释放速率几乎保持恒定。BH在pH 1.4时的释放速率高于pH 7.4时。
结论
β-CDP微球可能是一种理想的控释药物载体。
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