College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, Jiangsu, PR China.
Carbohydr Polym. 2013 Jun 5;95(1):366-70. doi: 10.1016/j.carbpol.2013.03.020. Epub 2013 Mar 13.
A water-soluble inclusion complex of hypericin (HY) with β-cyclodextrin polymer (CDP) was achieved by supramolecular interactions between HY and CDP. The inclusion complex (HY-CDP) was characterized by (1)H NMR, FTIR, and UV-vis spectroscopies. Compared with HY, the water-solubility of HY-CDP was greatly enhanced because of the water-soluble CDP host. The mole ratio of β-cyclodextrin (β-CD) unit in CDP to HY was determined as 2:1. At 25 °C, the dissociated constant of HY-CDP was measured as 1.47×10(-7) mol L(-1) by UV-vis spectroscopy. In the formation of inclusion complexes, CDP could overcome the β-CD drawbacks - such as the poor water-solubility and the restriction of single cavity size, indicating it was able to use as a universal solubilizer for pharmaceutical application.
通过大黄素（HY）与β-环糊精聚合物（CDP）之间的超分子相互作用，实现了大黄素的水溶性包合物（HY-CDP）。通过（1）H NMR、FTIR 和 UV-vis 光谱对包合物进行了表征。与 HY 相比，由于水溶性 CDP 主体的存在，HY-CDP 的水溶性大大提高。CDP 中 β-环糊精（β-CD）单元与 HY 的摩尔比确定为 2:1。在 25°C 下，通过 UV-vis 光谱法测定 HY-CDP 的离解常数为 1.47×10(-7) mol L(-1)。在形成包合物的过程中，CDP 克服了 β-CD 的缺点——例如水溶性差和单一空腔尺寸的限制，表明它可以用作药物应用的通用增溶剂。
