Avetisov E S, Vinetskaia M I, Iomdina E N, Makhmudova F R, Boltaeva Z K, Tarutta E P
Vestn Oftalmol. 1991 Sep-Oct;107(5):31-4.
Copper measurements in scleral tissue of 14 cadaveric emmetropic eyes and in 10 eyes with myopia of various degrees have shown a significant reduction of these levels in the equatorial and posterior segments of myopic sclera and abnormal distribution of copper in the tissue, this indicating disordered metabolism of this trace element. A method for drug correction of the detected disorder has been experimentally tried, consisting in administration under the Tenon's capsule of a copper coordination compound on a foam composition base, used for sclera-fortifying injections in progressive myopia. This resulted in elevation of scleral copper concentration, activization of collagen biosynthesis processes, and improvement of scleral tissue elasticity.
对14只尸体正视眼和10只不同程度近视眼的巩膜组织进行铜含量测定，结果显示，近视巩膜赤道部和后部的铜含量显著降低，且组织中铜分布异常，这表明该微量元素代谢紊乱。已通过实验尝试了一种药物纠正所检测到的紊乱的方法，即通过在Tenon囊下注射一种基于泡沫组合物的铜配位化合物，该化合物用于进行性近视的巩膜强化注射。这导致巩膜铜浓度升高、胶原生物合成过程激活以及巩膜组织弹性改善。
