Nozoe Tadahiro, Oyama Tsunehiro, Takenoyama Mitsuhiro, Hanagiri Takeshi, Sugio Kenji, Yasumoto Kosei
Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Clin Cancer Res. 2007 Jul 15;13(14):4046-50. doi: 10.1158/1078-0432.CCR-07-0449.
Possible significance of sex hormone estrogen as an antitumor therapeutic arm toward esophageal squamous cell carcinoma (ESCC) cells has been suggested. The aim of the current study was to clarify the clinicopathologic significance of an immunohistochemical expression of estrogen receptors alpha and beta (ER alpha and ER beta) in ESCC.
Expression of ER alpha and ER beta were examined using an immunohistochemical methods in 73 paraffin-embedded sections collected from patients with ESCC who had been subjected to esophageal resection and digestive reconstruction without any preoperative induction therapy.
Forty-seven (64.4%) ESCCs had a positive cytoplasmic expression of ER alpha and 21 (28.8%) ESCCs had a positive nuclear expression of ER beta. Univariate analysis showed that both positive ER alpha expression (P=0.0001) and negative ER beta expression (P=0.026) were unfavorable prognostic indicators in ESCC. Moreover, multivariate analysis showed that ER alpha-positive/ER beta-negative expression (P=0.003) and progression of tumor stage (P=0.014) were found to be independent unfavorable prognostic indicators in ESCCs.
Immunohistochemical expression of ER alpha and ER beta were found to be observed in ESCC. Positive expression of ER alpha in addition to negative expression of ER beta proved to be an unfavorable independent prognostic indicator in ESCC.
已有人提出性激素雌激素作为食管癌鳞状细胞癌（ESCC）细胞抗肿瘤治疗手段的潜在意义。本研究的目的是阐明雌激素受体α和β（ERα和ERβ）免疫组化表达在ESCC中的临床病理意义。
采用免疫组化方法检测73例接受食管切除及消化道重建且未进行任何术前诱导治疗的ESCC患者石蜡包埋切片中ERα和ERβ的表达。
47例（64.4%）ESCCs有ERα阳性细胞质表达，21例（28.8%）ESCCs有ERβ阳性核表达。单因素分析显示，ERα阳性表达（P=0.0001）和ERβ阴性表达（P=0.026）均为ESCC不良预后指标。此外，多因素分析显示，ERα阳性/ERβ阴性表达（P=0.003）和肿瘤分期进展（P=0.014）是ESCC独立的不良预后指标。
在ESCC中发现了ERα和ERβ的免疫组化表达。ERα阳性表达加上ERβ阴性表达被证明是ESCC不良的独立预后指标。
