Potthoff Anja, Brockmeyer Norbert
Klinik für Dermatologie und Allergologie der Ruhr-Universität Bochum, St. Josef-Hospital, Bochum, Germany.
Med Klin (Munich). 2007 Jul 15;102(7):531-9. doi: 10.1007/s00063-007-1067-7.
There is hardly any other medical field that has experienced changes and developments as dramatic as in the treatment of HIV infection in the last years. In Germany, 19 antiretroviral substances have been approved. New substances are effective in multidrug resistance viruses. The classes of CCR5 receptor antagonists and integrase inhibitors are new therapeutic options for heavily pretreated patients. In spite of this success many problems remain unsolved, e.g., lipodystrophy, osteoporosis, cardiovascular diseases and an increased number of tumors. Once more, the ideal point of treatment initiation needs to be discussed. Treating early prevents new infections and improves the course of HIV infection.
几乎没有任何其他医学领域在过去几年中经历过像艾滋病毒感染治疗那样剧烈的变化和发展。在德国，已有19种抗逆转录病毒药物获批。新药物对多重耐药病毒有效。CCR5受体拮抗剂和整合酶抑制剂类别为经过大量治疗的患者提供了新的治疗选择。尽管取得了这一成功，但许多问题仍未得到解决，例如脂肪代谢障碍、骨质疏松、心血管疾病以及肿瘤数量增加。治疗起始的理想时机需要再次进行讨论。早期治疗可预防新的感染并改善艾滋病毒感染的病程。
