通过兔微粒体代谢体外形成的新型苯环利定代谢物的鉴定。
Identification of novel phencyclidine metabolites formed in vitro by rabbit microsomal metabolism.
作者信息
Herber R, Perrin R, Ziegler J M, Villoutreix J, Minn A, Siest G
机构信息
URA, CNRS no. 597, Centre du Médicament, Nancy, France.
出版信息
Xenobiotica. 1991 Nov;21(11):1493-9. doi: 10.3109/00498259109044399.
PMID:1763523
Abstract
- Phencyclidine (PCP) was incubated with rabbit liver and brain microsomal fractions, and the structures of metabolites formed by oxidation determined by g.l.c.-mass spectrometry. 2. The formation of several known mono- and di-hydroxylated metabolites, as well as two new metabolites, was seen in the liver preparations. 3. Hydroxylated PCP metabolites were also formed after incubation of PCP with brain microsomes, indicating that PCP biotransformation may occur in the brain itself.
摘要
- 将苯环己哌啶（PCP）与兔肝和脑微粒体组分一起孵育，通过气相色谱-质谱法测定氧化形成的代谢物结构。2. 在肝脏制剂中观察到几种已知的单羟基和二羟基代谢物以及两种新代谢物的形成。3. 将PCP与脑微粒体孵育后也形成了羟基化的PCP代谢物，这表明PCP的生物转化可能在脑本身中发生。
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