神经细胞黏附分子（CD56）阳性B细胞淋巴瘤

Neural cell adhesion molecule (CD56)-positive B-cell lymphoma.

作者信息

Isobe Yasushi, Sugimoto Koichi, Takeuchi Kengo, Ando Jun, Masuda Azuchi, Mori Takeshi, Oshimi Kazuo

机构信息

Department of Hematology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.

出版信息

Eur J Haematol. 2007 Aug;79(2):166-9. doi: 10.1111/j.1600-0609.2007.00893.x.

DOI:10.1111/j.1600-0609.2007.00893.x

PMID:17635242

Abstract

Expression of neural cell-adhesion molecule CD56 is a rare event in B-cell lymphoma. We described four cases of CD56-positive B-cell lymphoma, including follicular lymphoma and diffuse large B-cell lymphoma. These lymphoma cells expressed CD10 and bcl-6, which suggests germinal center-stage phenotype. Immunohistochemistry showed that CD56-positive cells aggregated and displayed a cohesive growth pattern, indicating that homotypic adhesion through the molecules might affect the manner of tumor growth and expansion. Although CD56 expression level varies among the cases, this molecule might play some roles in the manner of growth and expansion of CD56-positive B-cell lymphomas.

摘要

神经细胞黏附分子CD56在B细胞淋巴瘤中的表达是罕见事件。我们描述了4例CD56阳性的B细胞淋巴瘤，包括滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤。这些淋巴瘤细胞表达CD10和bcl-6，提示为生发中心阶段表型。免疫组织化学显示CD56阳性细胞聚集并呈现黏附性生长模式，表明通过这些分子的同型黏附可能影响肿瘤生长和扩散方式。尽管各病例中CD56表达水平有所不同，但该分子可能在CD56阳性B细胞淋巴瘤的生长和扩散方式中发挥某些作用。