Gualco Gabriela, Bacchi Carlos E
Consultoria em Patologia, Botucatu, Sao Paulo, Brazil.
Int J Surg Pathol. 2008 Oct;16(4):407-13. doi: 10.1177/1066896908316784. Epub 2008 May 14.
Breast involvement by non-Hodgkin lymphomas is rare. We studied the morphological, immunophenotypical, and clinical features of 53 cases of malignant lymphomas involving the breast in a population of Brazilian patients. Most of the cases were of B-cell phenotype. Four of the patients with primary breast lymphomas had T-cell lymphomas, 3 had CD30-positive anaplastic large cell lymphomas, and 1 had panniculitis-like T-cell lymphoma. Most patients presented with an incidental breast mass. Secondary breast lymphoma was seen in 19 patients and most commonly occurred as part of widespread nodal disease. Two patients presented with bilateral breast involvement. The most prevalent histological subtype was also diffuse large B-cell lymphoma, followed by follicular lymphoma. This study shows that the broad morphological and immunophenotypical spectrum of malignant lymphoma of the breast occurring in a large series of Brazilian patients has many similarities with that seen in Western countries, with a higher proportion of high-grade lymphomas in both primary and secondary cases.
非霍奇金淋巴瘤累及乳腺的情况较为罕见。我们研究了巴西患者群体中53例累及乳腺的恶性淋巴瘤的形态学、免疫表型及临床特征。大多数病例为B细胞表型。4例原发性乳腺淋巴瘤患者为T细胞淋巴瘤，3例为CD30阳性间变性大细胞淋巴瘤，1例为脂膜炎样T细胞淋巴瘤。大多数患者表现为偶然发现的乳腺肿块。19例患者出现继发性乳腺淋巴瘤，最常见的是作为广泛淋巴结疾病的一部分。2例患者表现为双侧乳腺受累。最常见的组织学亚型也是弥漫性大B细胞淋巴瘤，其次是滤泡性淋巴瘤。这项研究表明，在大量巴西患者中发生的乳腺恶性淋巴瘤，其广泛的形态学和免疫表型谱与西方国家所见有许多相似之处，原发性和继发性病例中高级别淋巴瘤的比例均较高。
