Fleckeisen C E, Harrison R V, Mount R J
Department of Physiology, University of Toronto, Ontario, Canada.
Acta Otolaryngol Suppl. 1991;489:23-31. doi: 10.3109/00016489109127704.
In cochleas of chincillas treated with amikacin, cochlear sensory cells were totally destroyed in all new-born animals. In animals treated as adults some occasional haircells remained in apical turns. In the neonatally treated animals, the resulting auditory deprivation significantly affected the volume of the ventral cochlear nucleus and large-dark spherical cell area. The density of large-dark spherical cells increased significantly from normal in both neonatally and adult treated groups. Our results suggest that the VCN is more dependent on auditory stimulation for proper development than the DCN. In adult chinchillas treated with amikacin there was a significant change in large-dark spherical cell density without a change in total cell numbers or large-dark spherical cell area volume. Our study indicates that the mature cochlear nucleus is much more resistant to the effects of auditory deprivation than the developing cochlear nucleus and that the maintenance of the mature auditory system is not as dependent on auditory stimulation. Studies such as this examining the morphological effects of profound cochlear deafness on higher levels of the auditory system are essential in cochlear implant research.
在用阿米卡星治疗的栗鼠耳蜗中，所有新生动物的耳蜗感觉细胞均被完全破坏。在成年期接受治疗的动物中，偶尔有一些毛细胞保留在蜗顶。在新生期接受治疗的动物中，由此导致的听觉剥夺显著影响了蜗腹侧核和大的深色球形细胞区域的体积。在新生期和成年期接受治疗的组中，大的深色球形细胞的密度均较正常显著增加。我们的结果表明，与背侧蜗核相比，蜗腹侧核对适当发育的听觉刺激更为依赖。在用阿米卡星治疗的成年栗鼠中，大的深色球形细胞密度有显著变化，但细胞总数或大的深色球形细胞区域体积没有变化。我们的研究表明，成熟的蜗神经核比发育中的蜗神经核对听觉剥夺的影响更具抵抗力，并且成熟听觉系统的维持对听觉刺激的依赖性较小。此类研究，即研究严重耳蜗性耳聋对听觉系统更高层次的形态学影响，在人工耳蜗研究中至关重要。
