影响凝血酶激活的纤溶抑制物热稳定性和活性的1040C/T多态性与口腔癌风险相关。

The 1040C/T polymorphism influencing thermal stability and activity of thrombin activatable fibrinolysis inhibitor is associated with risk for oral cancer.

作者信息

Vairaktaris Eleftherios, Yapijakis Christos, Nkenke Emeka, Vassiliou Stavros, Vylliotis Antonis, Nixon Alexander Michael, Derka Spyridoula, Ragos Vasilis, Spyridonidou Sofia, Tsigris Christos, Neukam Friedrich W, Patsouris Efstratios

机构信息

Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Vas. Sofias 93 & Dim. Soutsou 1, Athens 11521, Greece.

出版信息

Am J Hematol. 2007 Nov;82(11):1010-2. doi: 10.1002/ajh.20985.

DOI:10.1002/ajh.20985

PMID:17636471

Abstract

No studies thus far have investigated the contribution of thrombin activatable fibrinolysis inhibitor (TAFI) to oral oncogenesis. We studied the activity-related 1040C/T polymorphism in 150 patients with oral cancer and 138 healthy controls matched by age, gender, and ethnicity. The increased-activity T allele frequency was significantly reduced in patients compared with controls (28.7% vs. 37.0%, P < 0.05). T/T homozygotes had about half the probability of developing oral cancer (O.R. 0.39, 95%C.I. 0.13-1.14), while no significant difference was observed in C/T heterozygotes. The observed prophylactic effect of increased TAFI activity might result from reduction of plasmin and inhibition of extracellular matrix dissolution.

摘要

迄今为止，尚无研究调查凝血酶激活的纤维蛋白溶解抑制剂（TAFI）在口腔肿瘤发生中的作用。我们研究了150例口腔癌患者和138例年龄、性别和种族相匹配的健康对照者中与活性相关的1040C/T多态性。与对照组相比，患者中活性增加的T等位基因频率显著降低（28.7%对37.0%，P<0.05）。T/T纯合子患口腔癌的概率约为一半（比值比0.39，95%可信区间0.13 - 1.14），而C/T杂合子未观察到显著差异。观察到的TAFI活性增加的预防作用可能是由于纤溶酶减少和细胞外基质溶解受到抑制。