Burton M J, Doree C
Cochrane ENT Disorders Group, Department of Otolaryngology - Head and Neck Surgery, Level LG1, West Wing, John Radcliffe Hospital, Oxford, UK, OX3 9DU.
Cochrane Database Syst Rev. 2007 Jul 18(3):CD004619. doi: 10.1002/14651858.CD004619.pub2.
Tonsillectomy is one of the most commonly performed surgical procedures. There are several operative methods currently in use, but the superiority of one over another has not been clearly demonstrated.
To assess the effectiveness of coblation tonsillectomy compared with other surgical techniques in reducing morbidity.
We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 4, 2006), MEDLINE (1966 to 2006) and EMBASE (1974 to 2006). The date of the last search was December 2006.
Randomised controlled trials of children and adults undergoing tonsillectomy by means of coblation compared with any other surgical technique for removal of the tonsils. Trials were assessed for methodological quality according to the method outlined in the Cochrane Handbook for Systematic Reviews of Interventions 4.2.6.
Data were extracted using standardised data extraction forms. Authors were contacted where additional data were required.
Nineteen studies were identified with sufficient data for further assessment. Four of these were excluded because intra-capsular tonsillectomy (i.e. tonsillotomy) rather than sub-capsular tonsillectomy was performed, and a further five studies because tonsils rather than participants were randomised. One further study was excluded because, although describing itself as a randomised trial, its participants turned out not to have been randomised to their intervention groups. Nine trials met the inclusion criteria, comparing coblation to other tonsillectomy techniques. All but two studies were of low quality and therefore a meta-analytical approach was not appropriate. In most studies, when considering most outcomes, there was no significant difference between coblation and other tonsillectomy techniques.
AUTHORS' CONCLUSIONS: In terms of postoperative pain and speed and safety of recovery, there is inadequate evidence to determine whether coblation tonsillectomy is better or worse than other methods of tonsillectomy. Evidence from a large prospective audit suggests that it has been associated with a higher level of morbidity, in terms of postoperative bleeding. Large, well-designed randomised controlled trials supplemented by data from large prospective audits are needed to produce information on effectiveness and morbidity respectively.
扁桃体切除术是最常施行的外科手术之一。目前有几种手术方法在使用,但一种方法相对于另一种方法的优越性尚未得到明确证明。
评估低温等离子扁桃体切除术与其他手术技术相比在降低发病率方面的有效性。
我们检索了Cochrane耳、鼻、喉疾病组试验注册库、Cochrane对照试验中央注册库(CENTRAL)(《Cochrane图书馆》2006年第4期)、MEDLINE(1966年至2006年)和EMBASE(1974年至2006年)。最后一次检索日期为2006年12月。
将接受低温等离子扁桃体切除术的儿童和成人与任何其他扁桃体切除手术技术进行比较的随机对照试验。根据《Cochrane干预措施系统评价手册》4.2.6中概述的方法对试验的方法学质量进行评估。
使用标准化数据提取表提取数据。在需要额外数据时与作者联系。
确定了19项有足够数据可进一步评估的研究。其中4项因施行的是囊内扁桃体切除术(即扁桃体切开术)而非囊下扁桃体切除术而被排除,另有5项研究因随机分组的是扁桃体而非参与者而被排除。还有1项研究被排除,因为尽管其自称是随机试验,但其参与者实际上并未被随机分配到干预组。9项试验符合纳入标准,将低温等离子扁桃体切除术与其他扁桃体切除技术进行了比较。除两项研究外,所有研究质量都很低,因此荟萃分析方法不合适。在大多数研究中,考虑大多数结果时,低温等离子扁桃体切除术与其他扁桃体切除技术之间没有显著差异。
在术后疼痛、恢复速度和安全性方面,没有足够的证据来确定低温等离子扁桃体切除术比其他扁桃体切除方法更好还是更差。来自大型前瞻性审计的证据表明,就术后出血而言,它与更高的发病率相关。需要大型、设计良好的随机对照试验,并辅以大型前瞻性审计的数据,分别得出关于有效性和发病率的信息。