麻醉药已知的亚细胞效应在完整心肌中对其负性肌力作用的影响。

Contribution of the known subcellular effects of anesthetics to their negative inotropic effect in intact myocardium.

作者信息

Komai H, Rusy B F

机构信息

Department of Anesthesiology, University of Wisconsin, Madison 53792.

出版信息

Adv Exp Med Biol. 1991;301:115-23. doi: 10.1007/978-1-4684-5979-1_11.

DOI:10.1007/978-1-4684-5979-1_11

PMID:1763690

Abstract

The results of these studies suggest that halothane, in addition to its effect of reducing the trans-sarcolemmal Ca2+ influx, has a direct effect on the function of the sarcoplasmic reticulum by making the organelle leaky to Ca2+ and reducing the amount of Ca2+ stored. Isoflurane, on the other hand, does not appear to make the sarcoplasmic reticulum leaky to Ca2+. In fact, our observations suggest that isoflurane makes the sarcoplasmic reticulum less leaky to Ca2+. Halothane may enhance the reduction in the myofibrillar response to activator Ca2+ when the muscle fiber length is shortened. Thiopental appears to reduce the trans-sarcolemmal Ca2+ influx without reducing the amount of Ca2+ stored in the sarcoplasmic reticulum.

摘要

这些研究结果表明，氟烷除了具有减少跨肌膜Ca2+内流的作用外，还通过使肌浆网对Ca2+渗漏以及减少Ca2+储存量，对肌浆网的功能产生直接影响。另一方面，异氟烷似乎不会使肌浆网对Ca2+渗漏。事实上，我们的观察结果表明，异氟烷使肌浆网对Ca2+的渗漏减少。当肌肉纤维长度缩短时，氟烷可能会增强肌原纤维对激活剂Ca2+反应的降低。硫喷妥似乎能减少跨肌膜Ca2+内流，而不减少肌浆网中Ca2+的储存量。