通过锆茂催化的烯基取代环状烯醇醚的串联形式扩环-镁化反应合成中等大小的碳环化合物。

Medium-sized carbocycles by a zirconocene-catalyzed tandem formal ring expansion-magnesation reaction of alkenyl-substituted cyclic enol ethers.

作者信息

Barluenga José, Alvarez-Rodrigo Lucía, Rodríguez Félix, Fañanás Francisco J

机构信息

Instituto Universitario de Química OrganometAlica Enrique Moles, Unidad Asociada al CSIC, Universidad de Oviedo, JuliAn Clavería 8, 33006-Oviedo, Spain.

出版信息

Org Lett. 2007 Aug 2;9(16):3081-4. doi: 10.1021/ol071137y. Epub 2007 Jul 17.

DOI:10.1021/ol071137y

PMID:17637021

Abstract

A new regio- and stereoselective zirconocene-catalyzed reaction for the synthesis of medium-sized rings is described. The global reaction supposes a formal ring expansion of a cyclic enol ether to give a functionalized carbocycle.

摘要

本文描述了一种用于合成中环的新型区域和立体选择性锆茂催化反应。总体反应设想是环状烯醇醚进行形式上的扩环反应，以生成官能化的碳环。