一种由二氯二茂锆（ZrCp₂Cl₂）-二异丁基氢化铝（DIBAL-H）原位生成的便捷且纯正的二氯氢锆茂（HZrCp₂Cl）等效物。
A convenient and genuine equivalent to HZrCp2Cl generated in situ from ZrCp2Cl2-DIBAL-H.
作者信息
Huang Zhihong, Negishi Ei-ichi
机构信息
Herbert C. Brown Laboratories of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, USA.
出版信息
Org Lett. 2006 Aug 17;8(17):3675-8. doi: 10.1021/ol061202o.
[reaction: see text] Slow addition of 1 equiv of (i)Bu2AlH to ZrCp2Cl2 in THF provides a convenient route to either HZrCp2Cl-(i)Bu2AlCl (Reagent I) or HZrCp2Cl (Reagents II and III). The latter represents a highly convenient route to genuine HZrCp2Cl, while Reagent I is useful for regio- and stereoselective conversion of 1- and 2-alkynes into (E)-1-iodo-1-alkenes and (E)-2-iodo-2-alkenes, respectively.
[反应：见正文] 在四氢呋喃中向二氯二茂锆缓慢加入1当量的二异丁基氢化铝，提供了一条方便的路线来制备二氯二茂锆氢-二异丁基氯化铝（试剂I）或二氯二茂锆氢（试剂II和III）。后者是制备纯二氯二茂锆氢的非常方便的路线，而试剂I可分别用于将1-炔烃和2-炔烃区域选择性和立体选择性地转化为（E）-1-碘-1-烯烃和（E）-2-碘-2-烯烃。
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