Chen Chun-Chieh, Yen Chi-Hua, Wu Wei-Ya, Hu Suh-Woan, Chen Shiuan-Chih, Bell William R, Lee Meng-Chih
Department of Family Medicine Chung Shan Medical University Hospital, Taichung 402, Taiwan, China.
Chin Med J (Engl). 2007 Jul 5;120(13):1155-8.
The public vaccination program of hepatitis B virus (HBV) was launched during 1984 in Taiwan, China. However, the long-lasting protective efficacy of HBV vaccination among adolescents older than 15 years of age was seldom recorded.
A seroepidemiological survey was conducted among 4575 first-year university students in Taiwan, China during 2000 to 2003, including the serological data of HBV by testing HBV surface antigen (HBsAg), surface antibody (anti-HBs), HBV core antibody (anti-HBc) and demographic information.
HBsAg carrier rate among male university students born before the initiation of the HBV vaccination program decreased from 12.8% to 4.8% among those born after the vaccination program (P < 0.001, chi(2) test for linear trend). Similarly, HBsAg carrier rate among female university students born before the initiation of the HBV vaccination program decreased from 8.1% to 2.7% among those born after the vaccination program (P < 0.001, chi(2) test for linear trend). Both male and female students in eastern Taiwan had the highest HBsAg carrier rate compared with the other places. Using multiple logistic regression analysis, compared with students born after July 1984, the adjusted OR of HBsAg carrier rate decreased from 3.10 for students born before June 1981 to 1.56 for students born from July 1983 to June 1984 (95% CI 1.96 - 4.91, P < 0.001; 95% CI 1.06 - 2.28, P = 0.024; respectively).
Public vaccination provides long-lasting protection again HBV infection among the university students in Taiwan, China older than 18 years of age. There is a geographic variation of HBV infection among young adults in Taiwan, China.
1984年期间，中国台湾地区启动了乙肝病毒（HBV）公共疫苗接种计划。然而，15岁以上青少年接种乙肝疫苗的长期保护效果鲜有记录。
2000年至2003年期间，在中国台湾地区对4575名大学一年级学生进行了血清流行病学调查，包括通过检测乙肝表面抗原（HBsAg）、表面抗体（抗-HBs）、乙肝核心抗体（抗-HBc）获得的乙肝血清学数据以及人口统计学信息。
在乙肝疫苗接种计划启动前出生的男大学生中，HBsAg携带率从接种计划启动后出生的学生中的12.8%降至4.8%（P<0.001，线性趋势的卡方检验）。同样，在乙肝疫苗接种计划启动前出生的女大学生中，HBsAg携带率从接种计划启动后出生的学生中的8.1%降至2.7%（P<0.001，线性趋势的卡方检验）。与其他地区相比，中国台湾地区东部的男女生HBsAg携带率最高。采用多因素logistic回归分析，与1984年7月以后出生的学生相比，HBsAg携带率的校正OR值从1981年6月以前出生的学生的3.10降至1983年7月至1984年6月出生的学生的1.56（95%CI 1.96 - 4.91，P<0.001；95%CI 1.06 - 2.28，P = 0.024；分别）。
公共疫苗接种为中国台湾地区18岁以上大学生提供了针对HBV感染的长期保护。中国台湾地区年轻人中HBV感染存在地域差异。
