11例由大马蹄螺（鲍鱼样贝类）引起的过敏反应

[11 cases of anaphylaxis caused by grand keyhole limpet (abalone like shellfish)].

作者信息

Maeda S, Morikawa A, Kato M, Motegi Y, Shigeta M, Tokuyama K, Kuroume T, Naritomi Y, Suehiro K, Kusaba K

机构信息

Department of Pediatrics, Gunma University School of Medicine.

出版信息

Arerugi. 1991 Nov;40(11):1415-20.

PMID:1763963

Abstract

We reported 11 cases of patients who developed moderate to severe anaphylactic reactions induced by the ingestion of grand keyhole limpet (GKL) and abalone. Specific IgE-mediated hypersensitivity to these shellfish was demonstrated by history, skin prick test, RAST and immunoblotting. The RAST inhibition technique revealed cross antigenicity between GKL, abalone and keyhole limpet hemocyanin. By immunoblotting analysis, the major antigens of GKL are shown in the MW range of about 38 Kd and 80 Kd.

摘要

我们报告了11例因食用大马蹄螺（GKL）和鲍鱼而发生中度至重度过敏反应的患者。通过病史、皮肤点刺试验、放射性变应原吸附试验（RAST）和免疫印迹法证实了对这些贝类存在特异性IgE介导的超敏反应。RAST抑制技术揭示了GKL、鲍鱼和马蹄螺血蓝蛋白之间的交叉抗原性。通过免疫印迹分析，GKL的主要抗原显示在约38千道尔顿和80千道尔顿的分子量范围内。