[内皮素转化酶新肽底物的底物特异性研究]
[Study of substrate specificity of a new peptide substrate of endothelin converting enzyme].
作者信息
Gureeva T A, Kugaevskaia E V, Pozdnev V F, Prozorovskiĭ V N, Eliseeva Iu E, Solov'eva N I
出版信息
Biomed Khim. 2007 Mar-Apr;53(2):172-80.
PMID:17639718
Abstract
The new fluorogenic hexapeptide substrate CMC-Ala-Gly-Gly-Trp-Phe-Arg was used as substrate for endothelin-converting enzyme (ECE), angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). The specific inhibitors lisinopril (ACE) and thiorphan (NEP) were used for identification of these enzyme activities,
摘要
新型荧光六肽底物CMC-丙氨酸-甘氨酸-甘氨酸-色氨酸-苯丙氨酸-精氨酸被用作内皮素转化酶（ECE）、血管紧张素转化酶（ACE）和中性内肽酶（NEP）的底物。特异性抑制剂赖诺普利（ACE）和硫磷酰胺（NEP）被用于鉴定这些酶活性。
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