Chod J, Závadová E, Halaska M, Strnad P, Rob L, Fucíková T
Gynekologicko-porodnická klinika 2. LF UK, Praha.
Ceska Gynekol. 2007 Apr;72(2):112-5.
OBJECTIVE AND DESIGN OF STUDY: Determination of TGF-beta 1 levels in plasma of patients with operable breast cancer. The correlation of TGF levels with the stage of disease and other prognostic markers. Prospective study.
There were 36 patients fulfilling the entrance criteria included in the study. The blood samples were taken to set the plasma levels of TGF-beta before the operation, with no adjuvant therapy. 27 age matched healthy volunteers served as controls. The study was approved by ethical board and patients signed informed consent regarding blood sampling and results presentation. Differences between groups were determined using the Mann-Whitney U-test.
We proved that TGF-beta 1 levels are elevated in patients with operable breast cancer. Moreover, TGF-beta in plasma of patients with positive sentinel lymph node was significantly higher as compared to patients with negative sentinel node. Most important is the fact that patients involved in our study were in very early stages of disease.
TGF-beta 1 is marker correlating with breast cancer disease risk factors, especially with positive sentinel lymph node. We conclude that TGF is one of the early markers which may help define the risk of disease progression already before the operation.
研究目的与设计：测定可手术乳腺癌患者血浆中转化生长因子-β1（TGF-β1）水平。研究TGF水平与疾病分期及其他预后标志物的相关性。前瞻性研究。
36例符合入选标准的患者纳入研究。在未进行辅助治疗的情况下，于手术前采集血样以测定血浆中TGF-β的水平。27名年龄匹配的健康志愿者作为对照。本研究经伦理委员会批准，患者签署了关于血样采集及结果展示的知情同意书。采用Mann-Whitney U检验确定组间差异。
我们证实可手术乳腺癌患者的TGF-β1水平升高。此外，前哨淋巴结阳性患者血浆中的TGF-β显著高于前哨淋巴结阴性患者。最重要的是，参与本研究的患者处于疾病的极早期阶段。
TGF-β1是与乳腺癌疾病风险因素相关的标志物，尤其是与前哨淋巴结阳性相关。我们得出结论，TGF是早期标志物之一，可能有助于在手术前就确定疾病进展风险。
