Gruendel Sindy, Garcia Ada L, Otto Baerbel, Wagner Karen, Bidlingmaier Martin, Burget Lukas, Weickert Martin O, Dongowski Gerhard, Speth Maria, Katz Norbert, Koebnick Corinna
Dietary Fibre and the Metabolic Syndrome Research Group, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Br J Nutr. 2007 Dec;98(6):1170-7. doi: 10.1017/S0007114507777127. Epub 2007 Jul 19.
We have recently shown that a polyphenol-rich insoluble dietary fibre preparation from carob pulp (Ceratonia siliqua L; carob fibre) decreased postprandial acylated ghrelin, TAG and NEFA during an acute liquid meal challenge test. However, delayed effects of carob fibre consumption are unknown. Therefore, a randomized controlled crossover study in nineteen healthy volunteers consuming foods with or without 50 g carob fibre was conducted. On the subsequent day (day 2), glucose, TAG, total and acylated ghrelin as well as insulin, NEFA and leptin were assessed at baseline and at timed intervals for 300 min after ingestion of standardized bread. Consumption of carob fibre-enriched foods did not affect fasting concentrations of glucose, TAG, total ghrelin, NEFA, insulin and leptin. Fasting acylated ghrelin was increased on the day subsequent to carob fibre consumption compared with control (P = 0.046). After consumption of the standard bread on day 2, glucose response (P = 0.029) was increased, and TAG (P = 0.033) and NEFA (P < 0.001) responses were decreased compared with control. Postprandial responses of total and acylated ghrelin, insulin and leptin on day 2 were unaffected by carob fibre consumption the previous day. In conclusion, an increase in total and acylated plasma ghrelin accompanied by enhanced lipid metabolism after carob fibre consumption suggests higher lipid utilization and suppressed lipolysis on the day subsequent to carob fibre consumption. However, elevated glucose levels after carob fibre consumption need to be addressed in future studies.
我们最近发现，一种来自角豆果肉（角豆树；角豆纤维）的富含多酚的不溶性膳食纤维制剂，在急性流食挑战试验期间可降低餐后酰化胃饥饿素、甘油三酯（TAG）和非酯化脂肪酸（NEFA）。然而，食用角豆纤维的延迟效应尚不清楚。因此，我们对19名健康志愿者进行了一项随机对照交叉研究，让他们食用含有或不含50克角豆纤维的食物。在随后的一天（第2天），在摄入标准化面包后，于基线及之后300分钟的定时间隔评估葡萄糖、TAG、总胃饥饿素和酰化胃饥饿素，以及胰岛素、NEFA和瘦素。食用富含角豆纤维的食物对葡萄糖、TAG、总胃饥饿素、NEFA、胰岛素和瘦素的空腹浓度没有影响。与对照组相比，食用角豆纤维后的第二天，空腹酰化胃饥饿素有所增加（P = 0.046）。在第2天食用标准面包后，与对照组相比，葡萄糖反应增强（P = 0.029），TAG反应（P = 0.033）和NEFA反应降低（P < 0.001）。第2天总胃饥饿素、酰化胃饥饿素、胰岛素和瘦素的餐后反应不受前一天食用角豆纤维的影响。总之，食用角豆纤维后血浆总胃饥饿素和酰化胃饥饿素增加，同时脂质代谢增强，这表明在食用角豆纤维后的第二天脂质利用率更高，脂肪分解受到抑制。然而，食用角豆纤维后血糖水平升高的问题需要在未来的研究中加以解决。
