Zunft H J F, Lüder W, Harde A, Haber B, Graubaum H J, Koebnick C, Grünwald J
Institute for Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558, Bergholz-Rehbrücke, Germany.
Eur J Nutr. 2003 Oct;42(5):235-42. doi: 10.1007/s00394-003-0438-y.
Recently, insoluble fibre from carob pulp has been found to affect blood lipids in animals in a similar manner as soluble dietary fibre.
To investigate whether a carob pulp preparation containing high amounts of insoluble fibre has a beneficial effect on serum cholesterol in humans.
Volunteers (n = 58) with hypercholesterolemia were recruited to participate in a randomised, double- blind, placebo-controlled and parallel arm clinical study with a 6 week intervention phase. All participants consumed daily both, bread (two servings) and a fruitbar (one serving) either with (n = 29) or without (n = 29) a total amount of 15 g/d of a carob pulp preparation (carob fibre). Serum concentrations of total, LDL and HDL cholesterol and triglycerides were assessed at baseline and after week 4 and 6.
The consumption of carob fibre reduced LDL cholesterol by 10.5 +/- 2.2% (p = 0.010). The LDL:HDL cholesterol ratio was marginally decreased by 7.9 +/- 2.2 % in the carob fibre group compared to the placebo group (p = 0.058). Carob fibre consumption also lowered triglycerides in females by 11.3 +/- 4.5% (p = 0.030). Lipid lowering effects were more pronounced in females than in males.
Daily consumption of food products enriched with carob fibre shows beneficial effects on human blood lipid profile and may be effective in prevention and treatment of hypercholesterolemia.
最近发现，角豆果肉中的不溶性纤维对动物血脂的影响与可溶性膳食纤维类似。
调查含有大量不溶性纤维的角豆果肉制剂对人体血清胆固醇是否有有益作用。
招募了58名高胆固醇血症志愿者，参与一项为期6周干预期的随机、双盲、安慰剂对照平行组临床研究。所有参与者每天都食用面包（两份）和一根水果棒（一份），其中29人食用的食物中添加了总量为每天15克的角豆果肉制剂（角豆纤维），另外29人未添加。在基线以及第4周和第6周后评估总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯的血清浓度。
食用角豆纤维使低密度脂蛋白胆固醇降低了10.5±2.2%（p = 0.010）。与安慰剂组相比，角豆纤维组的低密度脂蛋白胆固醇与高密度脂蛋白胆固醇之比略有下降，为7.9±2.2%（p = 0.058）。食用角豆纤维还使女性的甘油三酯降低了11.3±4.5%（p = 0.030）。降血脂作用在女性中比在男性中更明显。
每日食用富含角豆纤维的食品对人体血脂状况有有益影响，可能对高胆固醇血症的预防和治疗有效。
