Simhandl Christian, Mersch Jens
Aö Krankenhaus Neunkirchen. www.simhandl.at
Neuropsychiatr. 2007;21(2):121-30.
Overview and discussion regarding the use and relevance of lithium as an therapeutic agent for bipolar disorder in general, with a special focus on pregnancy, suicidality and possible side-effects.
Literature was handsearched and by searches of medline with special interest in recent results and comparative studies.
Lithium is still of high importance in the treatment of bipolar disorder. It is unmatched regarding decades of clinical experience and scientific evidence. It has a proven efficacy in every spectrum of bipolar illness, with less profound data regarding acute bipolar depression. Especially long term treatment of bipolar patients with lithium shows clear clinical benefits i.e.: importance of a continuous setting, gain of mood stabilizing effect over time, no loss of efficacy, reduced morbidity and mortality.
Lithium should be regarded as a first line treatment for bipolar disorder.
总体概述和讨论锂作为双相情感障碍治疗药物的用途及相关性，特别关注妊娠、自杀倾向和可能的副作用。
通过手工检索文献以及检索医学期刊数据库（Medline），特别关注近期研究结果和比较研究。
锂在双相情感障碍的治疗中仍然非常重要。在数十年的临床经验和科学证据方面，它是无可匹敌的。它在双相情感障碍的各个方面都有已证实的疗效，不过关于急性双相抑郁的数据较少。特别是对双相情感障碍患者进行长期锂治疗显示出明显的临床益处，即：持续治疗的重要性、随着时间推移情绪稳定作用增强、疗效无丧失、发病率和死亡率降低。
锂应被视为双相情感障碍的一线治疗药物。
