Bouwman Brigitte M, Suffczynski Piotr, Midzyanovskaya Inna S, Maris Eric, van den Broek Philip L C, van Rijn Clementina M
NICI/Department of Biological Psychology, Radboud University Nijmegen, 6500 HE Nijmegen, The Netherlands.
Epilepsy Res. 2007 Aug;76(1):34-40. doi: 10.1016/j.eplepsyres.2007.06.006. Epub 2007 Jul 20.
The effects of vigabatrin, which increases GABA concentrations by inhibiting GABA transaminase, on spike and wave discharges (SWDs) in the electroencephalogram of WAG/Rij rats were studied. Vigabatrin increased the incidence and duration of the SWDs, suggesting a quantitative GABA(A)ergic involvement in the mechanism(s) underlying the starting and stopping of an ongoing SWD. Also, vigabatrin decreased the SWD peak frequency, suggesting an important role of GABA(B) in the mechanism(s) underlying the peak frequency of the SWDs. Vigabatrin gradually changed the course of the hazard rates of the SWD durations, suggesting a qualitative GABAergic role in the mechanism(s) underlying the stopping of an ongoing SWD.
研究了通过抑制γ-氨基丁酸转氨酶来增加γ-氨基丁酸（GABA）浓度的vigabatrin对WAG/Rij大鼠脑电图中棘波和慢波放电（SWDs）的影响。Vigabatrin增加了SWDs的发生率和持续时间，提示在正在进行的SWD起始和终止机制中存在定量的GABA能参与。此外，vigabatrin降低了SWD的峰值频率，提示GABA(B)在SWDs峰值频率机制中起重要作用。Vigabatrin逐渐改变了SWD持续时间的风险率进程，提示在正在进行的SWD终止机制中存在定性的GABA能作用。
