Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure.
作者信息
Petrashevskaya Natalia, Liggett Stephen B
出版信息
Cardiovasc Res. 2007 Sep 1;75(4):631-3. doi: 10.1016/j.cardiores.2007.07.005. Epub 2007 Jul 16.
Abstract
摘要
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Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure.α2C - 肾上腺素能受体对肾上腺髓质儿茶酚胺释放的严格控制影响心力衰竭易感性。
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Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction.杂合子α2C -肾上腺素能受体缺陷小鼠在横断主动脉缩窄后会发生心力衰竭。
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本文引用的文献
1
Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction.杂合子α2C -肾上腺素能受体缺陷小鼠在横断主动脉缩窄后会发生心力衰竭。
Cardiovasc Res. 2007 Sep 1;75(4):728-37. doi: 10.1016/j.cardiores.2007.05.017. Epub 2007 May 24.
2
Long-distance affair with adrenal GRK2 hangs up heart failure.肾上腺GRK2的长期作用与心力衰竭相关。
Nat Med. 2007 Mar;13(3):246-8. doi: 10.1038/nm0307-246.
3
Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure.肾上腺GRK2上调介导心力衰竭中的交感神经过度驱动。
Nat Med. 2007 Mar;13(3):315-23. doi: 10.1038/nm1553. Epub 2007 Feb 18.
4
Cardiac adrenoceptors: physiological and pathophysiological relevance.心脏肾上腺素能受体：生理及病理生理相关性
J Pharmacol Sci. 2006;100(5):323-37. doi: 10.1254/jphs.crj06001x. Epub 2006 Apr 13.
5
Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment.α2A - 肾上腺素能受体和α2C - 肾上腺素能受体形成同二聚体和异二聚体：异二聚体状态会损害激动剂促进的GRK磷酸化和β - 抑制蛋白募集。
Biochemistry. 2006 Apr 18;45(15):4760-7. doi: 10.1021/bi052074z.
6
Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.心脏突触前α2C肾上腺素能受体的多态性：具有单倍型特异性功能效应的多种基因内变异性。
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13020-5. doi: 10.1073/pnas.0405074101. Epub 2004 Aug 19.
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alpha2-adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse models.α2-肾上腺素能受体亚型——基因靶向小鼠模型中发现的新功能
Biol Cell. 2004 Jun;96(5):343-8. doi: 10.1016/j.biolcel.2004.03.006.
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Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes.α2-肾上腺素能受体亚型对肾上腺和交感神经儿茶酚胺释放的差异性调控
Mol Endocrinol. 2003 Aug;17(8):1640-6. doi: 10.1210/me.2003-0035. Epub 2003 May 22.
9
Beta-adrenergic receptors in the failing heart: the good, the bad, and the unknown.衰竭心脏中的β-肾上腺素能受体：有益之处、有害之处及未知情况。
J Clin Invest. 2001 Apr;107(8):947-8. doi: 10.1172/JCI12774.
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Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.复杂的启动子和编码区β2 - 肾上腺素能受体单倍型改变受体表达并预测体内反应性。
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10483-8. doi: 10.1073/pnas.97.19.10483.
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