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Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure.

作者信息

Petrashevskaya Natalia, Liggett Stephen B

出版信息

Cardiovasc Res. 2007 Sep 1;75(4):631-3. doi: 10.1016/j.cardiores.2007.07.005. Epub 2007 Jul 16.

DOI:10.1016/j.cardiores.2007.07.005
PMID:17643402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6092936/
Abstract
摘要

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1
Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure.α2C - 肾上腺素能受体对肾上腺髓质儿茶酚胺释放的严格控制影响心力衰竭易感性。
Cardiovasc Res. 2007 Sep 1;75(4):631-3. doi: 10.1016/j.cardiores.2007.07.005. Epub 2007 Jul 16.
2
Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction.杂合子α2C -肾上腺素能受体缺陷小鼠在横断主动脉缩窄后会发生心力衰竭。
Cardiovasc Res. 2007 Sep 1;75(4):728-37. doi: 10.1016/j.cardiores.2007.05.017. Epub 2007 May 24.
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Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.参与调节小鼠肾上腺髓质儿茶酚胺释放的α2-肾上腺素能受体亚型。
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α₂-Adrenoceptor-mediated inhibition of catecholamine release from the adrenal medulla of spontaneously hypertensive rats is preserved in the early stages of hypertension.α₂-肾上腺素能受体介导的自发性高血压大鼠肾上腺髓质儿茶酚胺释放抑制在高血压早期阶段得到保留。
Basic Clin Pharmacol Toxicol. 2011 Oct;109(4):253-60. doi: 10.1111/j.1742-7843.2011.00712.x. Epub 2011 May 26.
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Mol Endocrinol. 2003 Aug;17(8):1640-6. doi: 10.1210/me.2003-0035. Epub 2003 May 22.
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Beta-adrenoceptor polymorphisms and heart failure.β-肾上腺素能受体基因多态性与心力衰竭
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Blockade of β-adrenoceptors restores the GRK2-mediated adrenal α(2) -adrenoceptor-catecholamine production axis in heart failure.β-肾上腺素受体阻断恢复心力衰竭中 GRK2 介导的肾上腺 α(2) -肾上腺素能受体儿茶酚胺产生轴。
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Alpha- and beta-receptor control of catecholamine secretion from isolated adrenal medulla cells.α和β受体对分离的肾上腺髓质细胞儿茶酚胺分泌的控制。
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Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans.
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The alpha 2C Del322-325 adrenergic receptor polymorphism is not associated with heart failure due to idiopathic dilated cardiomyopathy in black Africans.α2C Del322 - 325肾上腺素能受体多态性与非洲黑人特发性扩张型心肌病所致心力衰竭无关。
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本文引用的文献

1
Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction.杂合子α2C -肾上腺素能受体缺陷小鼠在横断主动脉缩窄后会发生心力衰竭。
Cardiovasc Res. 2007 Sep 1;75(4):728-37. doi: 10.1016/j.cardiores.2007.05.017. Epub 2007 May 24.
2
Long-distance affair with adrenal GRK2 hangs up heart failure.肾上腺GRK2的长期作用与心力衰竭相关。
Nat Med. 2007 Mar;13(3):246-8. doi: 10.1038/nm0307-246.
3
Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure.肾上腺GRK2上调介导心力衰竭中的交感神经过度驱动。
Nat Med. 2007 Mar;13(3):315-23. doi: 10.1038/nm1553. Epub 2007 Feb 18.
4
Cardiac adrenoceptors: physiological and pathophysiological relevance.心脏肾上腺素能受体：生理及病理生理相关性
J Pharmacol Sci. 2006;100(5):323-37. doi: 10.1254/jphs.crj06001x. Epub 2006 Apr 13.
5
Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment.α2A - 肾上腺素能受体和α2C - 肾上腺素能受体形成同二聚体和异二聚体：异二聚体状态会损害激动剂促进的GRK磷酸化和β - 抑制蛋白募集。
Biochemistry. 2006 Apr 18;45(15):4760-7. doi: 10.1021/bi052074z.
6
Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.心脏突触前α2C肾上腺素能受体的多态性：具有单倍型特异性功能效应的多种基因内变异性。
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13020-5. doi: 10.1073/pnas.0405074101. Epub 2004 Aug 19.
7
alpha2-adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse models.α2-肾上腺素能受体亚型——基因靶向小鼠模型中发现的新功能
Biol Cell. 2004 Jun;96(5):343-8. doi: 10.1016/j.biolcel.2004.03.006.
8
Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes.α2-肾上腺素能受体亚型对肾上腺和交感神经儿茶酚胺释放的差异性调控
Mol Endocrinol. 2003 Aug;17(8):1640-6. doi: 10.1210/me.2003-0035. Epub 2003 May 22.
9
Beta-adrenergic receptors in the failing heart: the good, the bad, and the unknown.衰竭心脏中的β-肾上腺素能受体：有益之处、有害之处及未知情况。
J Clin Invest. 2001 Apr;107(8):947-8. doi: 10.1172/JCI12774.
10
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.复杂的启动子和编码区β2 - 肾上腺素能受体单倍型改变受体表达并预测体内反应性。
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10483-8. doi: 10.1073/pnas.97.19.10483.