痣的遗传易感性——一项双胞胎研究。
Genetic susceptibility to naevi--a twin study.
作者信息
Easton D F, Cox G M, Macdonald A M, Ponder B A
机构信息
Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey.
出版信息
Br J Cancer. 1991 Dec;64(6):1164-7. doi: 10.1038/bjc.1991.483.
Abstract
The risk of malignant melanoma to an individual is strongly related to their total number of benign melanocytic naevi. To investigate the possibility that numbers of naevi may have an inherited basis, naevi were examined in 23 monozygotic and 22 dizygotic twin pairs. A strong correlation in total numbers of naevi 3 mm or more in diameter was observed between MZ twins (intraclass correlation 0.83), but there was no significant correlation between DZ twins (correlation -0.24). There was no increased concordance in presence of naevi 5 mm or more over that expected by chance, for MZ or DZ twins. The results suggest a strong inherited basis for total naevus count and hence melanoma risk, perhaps involving a number of interacting genes.
摘要
个体患恶性黑色素瘤的风险与其良性黑素细胞痣的总数密切相关。为了研究痣的数量可能存在遗传基础的可能性，对23对同卵双胞胎和22对异卵双胞胎的痣进行了检查。在直径3毫米或更大的痣的总数方面，同卵双胞胎之间观察到很强的相关性（组内相关系数为0.83），而异卵双胞胎之间没有显著相关性（相关系数为-0.24）。对于同卵或异卵双胞胎，直径5毫米或更大的痣的出现率并没有高于偶然预期的一致性增加。结果表明痣的总数以及因此患黑色素瘤的风险有很强的遗传基础，可能涉及多个相互作用的基因。
相似文献
1
Genetic susceptibility to naevi--a twin study.
Br J Cancer. 1991 Dec;64(6):1164-7. doi: 10.1038/bjc.1991.483.
2
Heritability of naevus patterns in an adult twin cohort from the Brisbane Twin Registry: a cross-sectional study.
Br J Dermatol. 2016 Feb;174(2):356-63. doi: 10.1111/bjd.14291. Epub 2016 Jan 22.
3
Genetics of risk factors for melanoma: an adult twin study of nevi and freckles.
J Natl Cancer Inst. 2000 Mar 15;92(6):457-63. doi: 10.1093/jnci/92.6.457.
4
Risk Factors and Relationship of Cutaneous and Uveal Melanocytic Lesions in Monozygotic and Dizygotic Twin Pairs.
PLoS One. 2016 Aug 3;11(8):e0160146. doi: 10.1371/journal.pone.0160146. eCollection 2016.
5
Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population.
J Vasc Surg. 2010 Jan;51(1):3-7; discussion 7. doi: 10.1016/j.jvs.2009.08.036. Epub 2009 Nov 24.
6
Twin study of genetic and aging effects on X chromosome inactivation.
Eur J Hum Genet. 2005 May;13(5):599-606. doi: 10.1038/sj.ejhg.5201398.
7
Characteristics and concordance of autism spectrum disorders among 277 twin pairs.
Arch Pediatr Adolesc Med. 2009 Oct;163(10):907-14. doi: 10.1001/archpediatrics.2009.98.
8
Etiologic factors of breast cancer elucidated by a study of unselected twins.
J Natl Cancer Inst. 1980 Aug;65(2):285-98.
9
Lifestyle factors in monozygotic and dizygotic twins.
Genet Epidemiol. 1988;5(5):311-21. doi: 10.1002/gepi.1370050503.
10
Genetic considerations in nonsyndromic midline craniosynostoses: a study of twins and their families.
J Neurosurg. 2005 Oct;103(4 Suppl):353-6. doi: 10.3171/ped.2005.103.4.0353.
引用本文的文献
1
Melanoma Genomics.
Acta Derm Venereol. 2020 Jun 3;100(11):adv00138. doi: 10.2340/00015555-3493.
2
Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma.
Int J Cancer. 2016 Sep 15;139(6):1217-22. doi: 10.1002/ijc.30157. Epub 2016 May 30.
3
Genetic factors associated with naevus count and dermoscopic patterns: preliminary results from the Study of Nevi in Children (SONIC).
Br J Dermatol. 2015 Apr;172(4):1081-9. doi: 10.1111/bjd.13467. Epub 2015 Feb 15.
4
Vitamin D and melanoma.
Dermatoendocrinol. 2013 Jan 1;5(1):121-9. doi: 10.4161/derm.25244.
5
Clinical and histological characteristics of melanocytic nevus in external auditory canals and auricles.
Eur Arch Otorhinolaryngol. 2013 Nov;270(12):3035-42. doi: 10.1007/s00405-013-2368-5. Epub 2013 Jan 31.
6
Prevalence and characteristics of choroidal nevi: the multi-ethnic study of atherosclerosis.
Ophthalmology. 2011 Dec;118(12):2468-73. doi: 10.1016/j.ophtha.2011.05.007. Epub 2011 Aug 4.
7
Skin cancer screening behaviours among individuals with a strong family history of malignant melanoma.
Br J Cancer. 2010 Nov 9;103(10):1502-9. doi: 10.1038/sj.bjc.6605942. Epub 2010 Oct 26.
8
Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom.
Cancer Epidemiol Biomarkers Prev. 2010 Aug;19(8):2043-54. doi: 10.1158/1055-9965.EPI-10-0233. Epub 2010 Jul 20.
9
Estimating CDKN2A carrier probability and personalizing cancer risk assessments in hereditary melanoma using MelaPRO.
Cancer Res. 2010 Jan 15;70(2):552-9. doi: 10.1158/0008-5472.CAN-09-2653. Epub 2010 Jan 12.
10
A pooled analysis of melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes.
Int J Cancer. 2009 Jan 15;124(2):420-8. doi: 10.1002/ijc.23869.
本文引用的文献
1
Twin concordance for a binary trait. I. Statistical models illustrated with data on drinking status.
Acta Genet Med Gemellol (Roma). 1983;32(2):127-37. doi: 10.1017/s0001566000006413.
2
Pigmentary traits, ethnic origin, benign nevi, and family history as risk factors for cutaneous malignant melanoma.
J Natl Cancer Inst. 1984 Feb;72(2):257-66.
3
Cutaneous malignant melanoma and familial dysplastic nevi: evidence for autosomal dominance and pleiotropy.
Am J Hum Genet. 1986 Feb;38(2):188-96.
4
Clinical and genetic studies in six Dutch kindreds with the dysplastic naevus syndrome.
Ann Hum Genet. 1986 Jul;50(3):249-58. doi: 10.1111/j.1469-1809.1986.tb01046.x.
5
Melanocytic naevi and melanoma: an epidemiological perspective.
Br J Dermatol. 1987 Aug;117(2):137-46. doi: 10.1111/j.1365-2133.1987.tb04109.x.
6
Programs for Pedigree Analysis: MENDEL, FISHER, and dGENE.
Genet Epidemiol. 1988;5(6):471-2. doi: 10.1002/gepi.1370050611.
7
A method for analysing case-control studies with ordinal exposure variables.
Biometrics. 1985 Sep;41(3):609-21.
8
Epidemiology of melanocytic nevi.
Epidemiol Rev. 1989;11:204-21. doi: 10.1093/oxfordjournals.epirev.a036037.
9
The zygosity of twins: further evidence on the agreement between diagnosis by blood groups and written questionnaires.
J Biosoc Sci. 1976 Jul;8(3):263-6. doi: 10.1017/s0021932000010737.
10
Volunteer bias in twin research: the rule of two-thirds.
Soc Biol. 1978 Spring;25(1):1-9. doi: 10.1080/19485565.1978.9988312.
Zotero 插件