Ramla Mostafa M, Omar Mohamed A, Tokuda H, El-Diwani Hoda I
Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo, Egypt.
Bioorg Med Chem. 2007 Oct 1;15(19):6489-96. doi: 10.1016/j.bmc.2007.04.010. Epub 2007 Apr 10.
As a continuation to our previous work concerning antitumor benzimidazoles, we have synthesized series of new derivatives of 2-(1-benzyl-2-methyl-1H-benzimidazol-5-ylimino)-3-(substituted)-thiazolidin-4-one (6a-e), 3-(2-methyl-1H-benzimidazol-5-yl)-2-substituted-thiazolidin-4-one (9a-f) and we have studied their inhibitory activity against the Epstein-Barr virus-early antigen (EBV-EA) activation introduced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Compound 6d was found to be significantly active and compounds 5a and 6e were also active.
作为我们之前关于抗肿瘤苯并咪唑研究工作的延续，我们合成了一系列新的2-(1-苄基-2-甲基-1H-苯并咪唑-5-基亚氨基)-3-(取代)-噻唑烷-4-酮(6a - e)、3-(2-甲基-1H-苯并咪唑-5-基)-2-取代-噻唑烷-4-酮(9a - f)衍生物，并研究了它们对由12-O-十四烷酰佛波醇-13-乙酸酯(TPA)诱导的爱泼斯坦-巴尔病毒早期抗原(EBV-EA)激活的抑制活性。发现化合物6d具有显著活性，化合物5a和6e也具有活性。
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