Shimojima Naoki, Shimazu Motohide, Kikuchi Haruhito, Kawachi Shigeyuki, Tanabe Minoru, Hoshino Ken, Wakabayashi Go, Morikawa Yasuhide, Kitajima Masaki
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Clin Transplant. 2007 Jul-Aug;21(4):498-501. doi: 10.1111/j.1399-0012.2007.00676.x.
Alcohol dehydrogenase (ADH) is an enzyme specifically located in the cytoplasm of hepatocytes. The purpose of this study was to assess the potential usefulness of serum ADH activity as a biomarker of graft function following liver transplantation. Blood samples were obtained from 26 patients who underwent living-donor liver transplantation. In patients without any post-operative complication, serum ADH activity normalized at 2.9 +/- 1.2 d. Values of serum ADH activity were remarkably elevated in patients with vascular complications, whereas they were only slightly elevated or remained within the reference range in patients with acute cellular rejections. In vascular complications, serum ADH activity peaked prior to elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and once the cause of damage was resolved, the values returned to reference range more quickly than did ALT and AST. In conclusion, monitoring serum ADH activity in addition to ALT and AST may provide more sensitive ongoing graft status and valuable information for the differential diagnosis of vascular complications and acute cellular rejection.
乙醇脱氢酶（ADH）是一种特异性存在于肝细胞胞质中的酶。本研究的目的是评估血清ADH活性作为肝移植后移植物功能生物标志物的潜在效用。从26例接受活体肝移植的患者中采集血样。在没有任何术后并发症的患者中，血清ADH活性在2.9±1.2天恢复正常。血管并发症患者的血清ADH活性值显著升高，而急性细胞排斥反应患者的血清ADH活性仅略有升高或仍在参考范围内。在血管并发症中，血清ADH活性在丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）升高之前达到峰值，一旦损伤原因得到解决，其值恢复到参考范围的速度比ALT和AST更快。总之，除了监测ALT和AST外，监测血清ADH活性可能为移植物状态提供更敏感的动态信息，并为血管并发症和急性细胞排斥反应的鉴别诊断提供有价值的信息。
