Suto Y, Ishikawa Y, Kadota K
Chuou Livestock Hygiene Service Centre, 736 Urushiyama, Yamagata 990-2161, Sapporo, Japan.
J Comp Pathol. 2007 Aug-Oct;137(2-3):133-6. doi: 10.1016/j.jcpa.2007.05.002. Epub 2007 Jul 23.
A case of epithelioid variant of liposarcoma in a 31-month-old Japanese Black heifer is described. The tumour mass, which formed in the subcutis of the left cheek, was excised surgically, but this was followed by recurrence and metastasis to lymph nodes. The primary tumour was composed of sheets of lipid-laden cells, and anaplastic larger cells with eosinophilic or amphophilic cytoplasm were occasionally seen. In addition to vimentin and S-100 protein expression in the majority of tumour cells, squamous and non-squamous cytokeratins (CKs) were present, mainly in the larger cells, which predominated in the metastatic lesions. The expression of CKs was considered to be evidence of epithelioid differentiation.
本文描述了一例31月龄日本黑毛小母牛发生的脂肪肉瘤上皮样变种病例。肿瘤块形成于左脸颊皮下，经手术切除，但随后出现复发并转移至淋巴结。原发肿瘤由成片的充满脂质的细胞组成，偶尔可见具有嗜酸性或两性细胞质的间变较大细胞。除了大多数肿瘤细胞表达波形蛋白和S-100蛋白外，鳞状和非鳞状细胞角蛋白（CKs）也有表达，主要存在于较大细胞中，这些较大细胞在转移灶中占主导。CKs的表达被认为是上皮样分化的证据。
