Dieing Annette, Ahlers Olaf, Hildebrandt Bert, Kerner Thoralf, Tamm Ingo, Possinger Kurt, Wust Peter
Department of Oncology and Hematology, Charité Campus Mitte, University Medicine Berlin, Germany, Schumannstrasse 20/21, D-10117 Berlin, Germany.
Prog Brain Res. 2007;162:137-52. doi: 10.1016/S0079-6123(06)62008-6.
Therapeutical hyperthermia has been considered for cancer therapy since William Coley observed tumour remission after induction of fever by bacterial toxins at the end of the 19th century. Because fever is associated with a variety of immunological reactions, it has been suspected, that therapeutical hyperthermia might also activate the immune system in a reproducible manner and thereby positively influence the course of the disease. During the last decade, new insight has been gained regarding the immunological changes taking place during therapeutic hyperthermia. In this chapter, we review the most relevant data known about the effect of hyperthermia on the immune system with special focus on alterations induced by therapeutical whole-body hyperthermia (WBH) in cancer patients.
自19世纪末威廉·科利观察到细菌毒素诱导发热后肿瘤缓解以来，治疗性热疗一直被视为癌症治疗方法。由于发热与多种免疫反应相关，人们怀疑治疗性热疗也可能以可重复的方式激活免疫系统，从而对疾病进程产生积极影响。在过去十年中，人们对治疗性热疗期间发生的免疫变化有了新的认识。在本章中，我们回顾了关于热疗对免疫系统影响的最相关数据，特别关注癌症患者治疗性全身热疗（WBH）引起的变化。
