Nishimura T, Mori K, Uchida Y, Ohira T, Tamura K
Department of Neurosurgery, Kochi Medical School, Japan.
Childs Nerv Syst. 1991 Oct;7(6):316-26. doi: 10.1007/BF00304830.
Brain stem auditory-evoked potentials (BAEPs) were recorded in 30 patients with meningomyelocele and shunted hydrocephalus ranging in age from birth to 33 years. Twenty-two of them had Chiari II malformation, one of which was symptomatic. In 22 cases, including 15 with Chiari II malformation, BAEPs were recorded repeatedly after periods ranging from 18 months to 7 years. The results were as follows: (1) III-V interpeak latency (IPL) decreased progressively from prolonged to the normal range with growth until 25 years of age; (2) I-III IPL tended to prolong gradually from the normal range; (3) these findings may indicate that the natural history of Chiari II malformation is delayed maturation of the brain stem and intensification in the elongation and stretching of the hindbrain and lower cranial nerves.
对30例年龄从出生至33岁的患有脊髓脊膜膨出和分流性脑积水的患者进行了脑干听觉诱发电位（BAEP）记录。其中22例患有Chiari II畸形，其中1例有症状。在22例患者中，包括15例患有Chiari II畸形的患者，在18个月至7年的时间段后重复记录BAEP。结果如下：（1）III-V峰间潜伏期（IPL）随着生长逐渐从延长缩短至正常范围，直至25岁；（2）I-III IPL倾向于从正常范围逐渐延长；（3）这些发现可能表明Chiari II畸形的自然病程是脑干成熟延迟以及后脑和下颅神经的延长和拉伸加剧。
