Kane R C, Cohen M H
JAMA. 1976 Apr 19;235(16):1717-8.
Among 38 patients with bronchogenic carcinoma, small-cell type, eight patients had superior vena caval obstruction (SVCO) of recent onset. Seven of these patients were initially treated with combination chemotherapy (lomustine, cyclophosphamide, and methotrexate). One patient who had SVCO was treated initially by radiotherapy, with subsequent chemotherapy. In each patient, resolution of the syndrome was prompt, usually was complete by seven days, and was accompanied by objective tumor shrinkage. Symptoms of SVCO were transiently aggravated by the initiation of treatment in only one patient. In one individual treated by chemotherapy alone and in one treated by chemotherapy plus radiotherapy, SVCO recurred after initial control. Chemotherapy is an effective form of management of SVCO caused by small-cell carcinoma of the lung.
在38例小细胞型支气管源性癌患者中，8例近期出现上腔静脉阻塞（SVCO）。其中7例患者最初接受联合化疗（洛莫司汀、环磷酰胺和甲氨蝶呤）。1例患有SVCO的患者最初接受放射治疗，随后进行化疗。在每例患者中，综合征的缓解迅速，通常在7天内完全缓解，并伴有客观的肿瘤缩小。仅1例患者在开始治疗时SVCO症状短暂加重。在1例仅接受化疗的患者和1例接受化疗加放疗的患者中，SVCO在最初得到控制后复发。化疗是治疗由肺小细胞癌引起的SVCO的一种有效方法。
