Dombernowsky P, Hansen H H
Acta Med Scand. 1978;204(6):513-6. doi: 10.1111/j.0954-6820.1978.tb08482.x.
Among 225 consecutive patients with small-cell anaplastic bronchogenic carcinoma, 26 (11.5%) had superior vena caval obstruction when the malignancy was diagnosed. Of these 26 patients, a consecutive series of 22 were treated initially with combination chemotherapy (cyclophosphamide, methotrexate and CCNU, in some cases combined with vincristine) alone, and in all these cases resolution of the syndrome was prompt within a median of 7 days. In no case were symptoms increased transiently by the treatment. No difference in response rate was observed between the histologic subtypes of small-cell anaplastic bronchogenic carcinoma according to the WHO classification. Combination chemotherapy alone is an effective treatment of superior vena caval obstruction in patients with small-cell anaplastic bronchogenic carcinoma.
在225例连续性小细胞间变性支气管癌患者中，26例（11.5%）在确诊恶性肿瘤时出现上腔静脉阻塞。在这26例患者中，连续22例最初仅接受联合化疗（环磷酰胺、甲氨蝶呤和洛莫司汀，部分病例联合长春新碱）治疗，所有这些病例中综合征在中位7天内迅速缓解。治疗过程中症状均未出现短暂加重。根据世界卫生组织分类，小细胞间变性支气管癌的组织学亚型之间在缓解率上未观察到差异。单纯联合化疗是小细胞间变性支气管癌患者上腔静脉阻塞的有效治疗方法。
